CAJ | 학술논문

目的：探讨肺心病及肺心病患者的心功能状态及低氧血症对QT间期离散度（QT离散度）的影响。方法：分析了51例肺心病患者及28例健康对照者的QT离散度、心电图、超声心动图及动脉血气分析。结果：肺心病患者的QT离散度显著高于正常对照者，两组分别为（70.1 ± 25.8） ms 和（37.6 ± 12.5 ）ms（P < 0.001）；心衰患者的QT离散度延长更为明显，为（87.9 ± 21.6） ms，无心衰患者为（51.7 ± 14.2） ms，两组比较差异非常显著（P< 0.001）；低氧血症对QT离散度有显著影响，动脉血氧分压（PaO2）< 8 kPa组和PaO2 ≥ 8kPa组QT离散度分别为（81.0 ± 25.9 ）ms和（62.1 ± 21.2） ms ，两组比较有显著差异（P< 0.01）；肺心病患者的QT离散度与右室内径大小显著正相关（r= 0.489，P< 0.01）。结论：QT离散度对于肺心病的辅助诊断及心功能判断具有一定的临床意义。
목적：탐토폐심병급폐심병환자적심공능상태급저양혈증대QT간기리산도（QT리산도）적영향。방법：분석료51례폐심병환자급28례건강대조자적QT리산도、심전도、초성심동도급동맥혈기분석。결과：폐심병환자적QT리산도현저고우정상대조자， 량조분별위（70.1 ± 25.8） ms 화（37.6 ± 12.5 ）ms（P < 0.001）；심쇠환자적QT리산도연장경위명현， 위（87.9 ± 21.6） ms，무심쇠환자위（51.7 ± 14.2） ms， 량조비교차이비상현저（P< 0.001）；저양혈증대QT리산도유현저영향，동맥혈양분압（PaO2）< 8 kPa조화PaO2 ≥ 8kPa조QT리산도분별위（81.0 ± 25.9 ）ms화（62.1 ± 21.2） ms ，량조비교유현저차이（P< 0.01）；폐심병환자적QT리산도여우실내경대소현저정상관（r= 0.489，P< 0.01）。결론：QT리산도대우폐심병적보조진단급심공능판단구유일정적림상의의。
Objective：Our aim was to investigate the QT dispersion in patients with cor pulmonale and whether the QT dispersion was affected by cardiac function and hypoxemia of the patients with cor pulmonale. Methods：Fifty-one patients with cor pulmonale and 28 age-matched normal controls underwent electrocardiography, echocardiography, and arterial blood gas analysis. The　QT　dispersion　was measured manually. Results:The QT dispersion was significantly longer in patients with cor pulmonale than those in the controls (70.1 ± 25.8 ms vs 37.6 ± 12.5 ms, P< 0.001). The QT dispersion in the patients with right heart failure was markedly longer compared with those with normal cardiac function (87.9 ± 21.6 ms vs 51.7 ± 14.2 ms, P<0.001). The QT dispersion was affected by hypoxemia. The QT dispersion in the groups of PaO2< 8 kPa　or ≥ 8 kPa was 81.0 ± 25.9 ms and 62.1 ± 21.1 ms, respectively. There was significant difference between the groups (P< 0.01). The QT dispersion was significantly correlated with the interior diameter of right ventricle in the patients with cor pulmonale (r= 0.489, P< 0.01). Conclusion: The QT dispersion may be a useful parameter in the diagnosis for cor pulmonale and in the assessment of cardiac function in the patients with cor pulmonale.