CAJ | 학술논문

目的：研究商陆皂苷甲（EsA）对脂多糖（LPS）刺激兔滑膜细胞产生白介素1（IL-1）和肿瘤坏死因子（TNF）的影响。方法：用胸腺细胞增殖法和用L929细胞作靶细胞的生物测定法，分别检测与EsA共育的受LPS刺激的兔滑膜细胞培养上清中IL-1和TNF的含量。结果：EsA在5～40 μg/ml范围内能明显抑制LPS诱导兔滑膜细胞产生IL-1和TNF。结论：EsA可抑制滑膜细胞产生IL-1和TNF的作用提示其可能有助于消除类风湿性关节炎的关节炎症。
목적：연구상륙조감갑（EsA）대지다당（LPS）자격토활막세포산생백개소1（IL-1）화종류배사인자（TNF）적영향。방법：용흉선세포증식법화용L929세포작파세포적생물측정법，분별검측여EsA공육적수LPS자격적토활막세포배양상청중IL-1화TNF적함량。결과：EsA재5～40 μg/ml범위내능명현억제LPS유도토활막세포산생IL-1화TNF。결론：EsA가억제활막세포산생IL-1화TNF적작용제시기가능유조우소제류풍습성관절염적관절염증。
Objective: To investigate the influence of esculentoside A（EsA） on production of IL-1 and TNF by rabbit synovial cells induced by LPS. Methods: levels of IL-1 and TNF in the supernatant of rabbit synovial cell were determined by examining proliferation of thymic cells and by bioassay L929 cells as target cells, respectively. Results: EsA in 5-40 μg/ml could significantly inhibit the production of IL-1 and TNF from rabbit synovial cells induced by LPS. Conclusion: EsA can inhibit the production of IL-1 and TNF from synovial cells. It suggests that EsA may play a role in improving the rheumatoid arthritis.