CAJ | 학술논문

目的:观察正畸力作用下IL-6在大鼠牙周组织内的表达分布及牙槽骨高度的改变,研究正畸力对牙周组织改建的作用.方法:将30 只SD大鼠随机分为空白对照组和加力组,施加0.49 N近中向正畸力于加力组25 只大鼠的左侧上颌第一磨牙.运用免疫组织化学及组织形态分析法观测各组大鼠上颌第一磨牙加力后0、1、3、5、7、10 d的IL-6表达量及牙槽骨吸收量.结果:加力组大鼠牙周组织内IL-6的表达在受力后第3天达到高峰,之后开始下降;其近中牙槽骨未见明显丧失.结论:正畸力虽可引发局部牙周组织的炎症反应及IL-6等促炎性细胞因子的释放,但具有一定的自限性,不会导致牙周组织的严重破坏和牙槽骨的明显吸收.
목적:관찰정기력작용하IL-6재대서아주조직내적표체분포급아조골고도적개변,연구정기력대아주조직개건적작용.방법:장30 지SD대서수궤분위공백대조조화가력조,시가0.49 N근중향정기력우가력조25 지대서적좌측상합제일마아.운용면역조직화학급조직형태분석법관측각조대서상합제일마아가력후0、1、3、5、7、10 d적IL-6표체량급아조골흡수량.결과:가력조대서아주조직내IL-6적표체재수력후제3천체도고봉,지후개시하강;기근중아조골미견명현상실.결론:정기력수가인발국부아주조직적염증반응급IL-6등촉염성세포인자적석방,단구유일정적자한성,불회도치아주조직적엄중파배화아조골적명현흡수.
Objective; To investigate the expression and distribution of IL-6 in periodontal tissues and the change of the alveolar bone of rats during orthodontic tooth movement, and to study the effects of orthodontic force on the periodontal tissue remodeling. Methods: SO gram orthodontic force was loaded on the left first maxillary molars of 25 rats in experimental group. Immunohistochem-istry and histomorphometric analysis were performed to measure the expression of IL-6 and the loss of alveolar bone at 0, 1, 3, 5, 7 " and 10 days after the application of orthodontic force. Results; The expression of IL-6 was observed to reach maximum level on day 3 and to decline thereafter in experimental group. No obvious alveolar bone loss was detected in the mesial side of the first molars. Conclusion; Although orthodontic force can evoke the local inflammatory response of periodontal tissue and the expression of pro-inflammation cytokines such as IL-6, it can not cause severe periodontal destruction and alveolar bone loss.