国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2010年
4期
343-344
,共2页
脑梗塞%蛋白%C反应蛋白质
腦梗塞%蛋白%C反應蛋白質
뇌경새%단백%C반응단백질
brain infarction%egg white%C-reactive protein
目的 探讨不同程度急性脑梗死患者血清S100B蛋白和超敏C反应蛋白(hs-CRP)含量与其脑梗死体积之间的关系.方法 采用电化学发光法和免疫透射比浊法,对56例急性脑梗死患者进行血清S100B蛋白和hs-CRP含量测定,并分析两者与急性脑梗死体积的相关性.结果 急性脑梗死患者血清S100B蛋白和hs-CRP含量显著高于健康对照组(P<0.01),其与梗死灶大小及临床预后有显著相关性.结论 S100B蛋白是1种神经胶质标志蛋白,作为急性脑梗死早期诊断敏感的生化指标,对判断急性脑梗死患者病变的严重程度、梗死体积的大小有较好的临床意义.hs-CRP是1种典型的急性期蛋白,CRP的合成与致炎性细胞因子有着密切的关系,其水平升高是炎性反应的1个重要生化指标.联合检测血清S100B蛋白及hs-CRP含量,对于判断急性脑梗死患者病情严重程度和梗死体积具有一定的临床意义.
目的 探討不同程度急性腦梗死患者血清S100B蛋白和超敏C反應蛋白(hs-CRP)含量與其腦梗死體積之間的關繫.方法 採用電化學髮光法和免疫透射比濁法,對56例急性腦梗死患者進行血清S100B蛋白和hs-CRP含量測定,併分析兩者與急性腦梗死體積的相關性.結果 急性腦梗死患者血清S100B蛋白和hs-CRP含量顯著高于健康對照組(P<0.01),其與梗死竈大小及臨床預後有顯著相關性.結論 S100B蛋白是1種神經膠質標誌蛋白,作為急性腦梗死早期診斷敏感的生化指標,對判斷急性腦梗死患者病變的嚴重程度、梗死體積的大小有較好的臨床意義.hs-CRP是1種典型的急性期蛋白,CRP的閤成與緻炎性細胞因子有著密切的關繫,其水平升高是炎性反應的1箇重要生化指標.聯閤檢測血清S100B蛋白及hs-CRP含量,對于判斷急性腦梗死患者病情嚴重程度和梗死體積具有一定的臨床意義.
목적 탐토불동정도급성뇌경사환자혈청S100B단백화초민C반응단백(hs-CRP)함량여기뇌경사체적지간적관계.방법 채용전화학발광법화면역투사비탁법,대56례급성뇌경사환자진행혈청S100B단백화hs-CRP함량측정,병분석량자여급성뇌경사체적적상관성.결과 급성뇌경사환자혈청S100B단백화hs-CRP함량현저고우건강대조조(P<0.01),기여경사조대소급림상예후유현저상관성.결론 S100B단백시1충신경효질표지단백,작위급성뇌경사조기진단민감적생화지표,대판단급성뇌경사환자병변적엄중정도、경사체적적대소유교호적림상의의.hs-CRP시1충전형적급성기단백,CRP적합성여치염성세포인자유착밀절적관계,기수평승고시염성반응적1개중요생화지표.연합검측혈청S100B단백급hs-CRP함량,대우판단급성뇌경사환자병정엄중정도화경사체적구유일정적림상의의.
Objective To explore the different levels of serum S100B protein in patients with cerebral infarction and high-sensitivity C-reactive protein(hs-CRP) concentration and its relationship between the volume of cerebral infarction.Methods Electrochemiluminescence transmission and immune turbidimetry of 56 cases of cerebral infarction patients with serum S100B protein and determination of hs-CRP,and analysis of both the volume and relevance of cerebral infarction.Results The serum S100B protein in patients with cerebral infarction and hs-CRP protein was significantly higher than the normal control group(P<0.01),concentration and infarct size and clinical prognosis in a significant correlation.Conclusion S100B protein is a glial marker proteins,as early diagnosis of cerebral infarction sensitive biological indicators of cerebral infarction patients to determine the severity of the lesion,the size of infarct volume have better clinical significance.hs-CRP is a typical acute phase protein,CRP-induced Synthesis and inflammatory cytokines are closely related,the higher the level of inflammatory response is an important biochemical indicators.Combined detection of serum S100B and hs-CRP for patients to judge the severity of cerebral infarct volume and clinical significance of a certain extent.
