同位素
同位素
동위소
ISOTOPES
2011年
2期
94-97
,共4页
卢霞%王荣福%闫平%周颖明%张一帆
盧霞%王榮福%閆平%週穎明%張一帆
로하%왕영복%염평%주영명%장일범
131I%octreotide%标记%Graves眼病%炎症细胞
131I%octreotide%標記%Graves眼病%炎癥細胞
131I%octreotide%표기%Graves안병%염증세포
将octreotide中的苯丙氨酸用酪氨酸替换合成[Tyr3]octreotide,对其进行了131I标记.考察了氯胺T标记法中氯胺T和[Tyr3]octreotide的用量对标记率的影响,观察了Graves眼病相关炎症细胞对131I-[Tyr3]octrotide的体外摄取情况.结果表明,对octreotide进行结构修饰后得到的[Tyr3]octreotide可以用于131I标记;氯胺T法对[Tyr3]octreotide进行131I标记时,氯胺T和[Tyr3]octreotide的最佳用量分别为1.6和1.4 μg,最高标记率为85%;T淋巴细胞、活化的成纤维细胞及血管内皮细胞均能够摄取131-[Tyr3]octreotide,而脂肪细胞的摄取则明显较少.以上结果表明,131I-[Tyr3]octreotide能够被Graves眼病发病过程中的炎症细胞摄取,具有用于Graves眼病发病过程中炎症反应程度评估的应用潜力.但由于摄取量还很小,需要进一步深入研究.
將octreotide中的苯丙氨痠用酪氨痠替換閤成[Tyr3]octreotide,對其進行瞭131I標記.攷察瞭氯胺T標記法中氯胺T和[Tyr3]octreotide的用量對標記率的影響,觀察瞭Graves眼病相關炎癥細胞對131I-[Tyr3]octrotide的體外攝取情況.結果錶明,對octreotide進行結構脩飾後得到的[Tyr3]octreotide可以用于131I標記;氯胺T法對[Tyr3]octreotide進行131I標記時,氯胺T和[Tyr3]octreotide的最佳用量分彆為1.6和1.4 μg,最高標記率為85%;T淋巴細胞、活化的成纖維細胞及血管內皮細胞均能夠攝取131-[Tyr3]octreotide,而脂肪細胞的攝取則明顯較少.以上結果錶明,131I-[Tyr3]octreotide能夠被Graves眼病髮病過程中的炎癥細胞攝取,具有用于Graves眼病髮病過程中炎癥反應程度評估的應用潛力.但由于攝取量還很小,需要進一步深入研究.
장octreotide중적분병안산용락안산체환합성[Tyr3]octreotide,대기진행료131I표기.고찰료록알T표기법중록알T화[Tyr3]octreotide적용량대표기솔적영향,관찰료Graves안병상관염증세포대131I-[Tyr3]octrotide적체외섭취정황.결과표명,대octreotide진행결구수식후득도적[Tyr3]octreotide가이용우131I표기;록알T법대[Tyr3]octreotide진행131I표기시,록알T화[Tyr3]octreotide적최가용량분별위1.6화1.4 μg,최고표기솔위85%;T림파세포、활화적성섬유세포급혈관내피세포균능구섭취131-[Tyr3]octreotide,이지방세포적섭취칙명현교소.이상결과표명,131I-[Tyr3]octreotide능구피Graves안병발병과정중적염증세포섭취,구유용우Graves안병발병과정중염증반응정도평고적응용잠력.단유우섭취량환흔소,수요진일보심입연구.
