CAJ | 학술논문

　　[目的]探讨血清中白介素6（IL-6）、IL-8、IL-10和肿瘤坏死因子（TNF-α）对于脑胶质瘤的诊断价值。[材料与方法]分别检测健康对照组、低级别脑胶质瘤组和高级别脑胶质瘤组中IL-6、IL-8、IL-10和TNF-α的含量。[结果]与健康对照组比较，低级别脑胶质瘤组的IL-6、IL-8和TNF-α有统计学差异，高级别脑胶质瘤组的IL-6、IL-8、IL-10和TNF-α均具有统计学差异。与低级别脑胶质瘤组相比较，高级别脑胶质瘤组的IL-6、IL-10和TNF-α有统计学差异。其中区分低级别脑胶质瘤和高级别脑胶质瘤的诊断价值最好的指标为IL-10，其诊断灵敏性和特异性分别为74.90%和65.80%。IL-6、IL-10和TNF-α联合检测时其灵敏性和特异性分别为92.30%和93.10%。[结论]证实IL-6、IL-10和TNF-α联合诊断价值优于单项指标，为脑胶质瘤的临床诊断提供辅助方法。
　　[목적]탐토혈청중백개소6（IL-6）、IL-8、IL-10화종류배사인자（TNF-α）대우뇌효질류적진단개치。[재료여방법]분별검측건강대조조、저급별뇌효질류조화고급별뇌효질류조중IL-6、IL-8、IL-10화TNF-α적함량。[결과]여건강대조조비교，저급별뇌효질류조적IL-6、IL-8화TNF-α유통계학차이，고급별뇌효질류조적IL-6、IL-8、IL-10화TNF-α균구유통계학차이。여저급별뇌효질류조상비교，고급별뇌효질류조적IL-6、IL-10화TNF-α유통계학차이。기중구분저급별뇌효질류화고급별뇌효질류적진단개치최호적지표위IL-10，기진단령민성화특이성분별위74.90%화65.80%。IL-6、IL-10화TNF-α연합검측시기령민성화특이성분별위92.30%화93.10%。[결론]증실IL-6、IL-10화TNF-α연합진단개치우우단항지표，위뇌효질류적림상진단제공보조방법。
[Purpose] To explore the diagnostic value of serum interleukin-6 (IL-6), IL-8, IL-10 and tumor necrosis factor (TNF-α) for glioma. [Materials and methods] The content of IL-6, IL-8, IL-10 and TNF-α in the healthy control group, the low-grade gliomas group and the high-grade gliomas group were detected by Luminex 200. [Results] Compared to the healthy control group, IL-6, IL-8, and TNF-α in the low-grade gliomas group showed significantly different, IL-6, IL-8, IL-10 and TNF-α in the high-level group of glioma showed significantly different. Compared to the low-grade gliomas Group, IL-6, IL-10 and TNF-α in the high-grade gliomas showed significantly different. When we discriminated the low-grade gliomas and high-grade gliomas, the best indicators was IL-10, and the diagnostic sensitivity and specificity were 74.90% and 65.80%, respectively. When the IL-6, IL-10 and TNF-α were combined, the sensitivity and specificity were 92.30% and 93.10%, respectively. [Conclusion] IL-6, IL-10 and TNF-α joint diagnostic value showed significant improvedment when compared to the individual indicators. It may provide a auxiliary method for brain the clinical diagnosis of glioma.