中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2008年
34期
24-27
,共4页
肺疾病%慢性阻塞性%胃食管反流%急性加重
肺疾病%慢性阻塞性%胃食管反流%急性加重
폐질병%만성조새성%위식관반류%급성가중
Pulmonary disease,chronic obstructive%Gastroesophageal reflux%Exacerbation
目的 探讨胃食管反流病(GERD)对慢性阻塞性肺疾病(COPD)急性加重的影响.方法 纳入本研究患者均确诊为COPD,均完成反流性疾病诊断问卷(RDQ),依据RDQ结果 分为GERD组(38例)和非GERD组(36例),比较两组患者的临床资料及每年COPD急性加重次数等.结果 与非GERD组比较,GERD组每年COPD急性加重次数增多[(2.68±0.77)次,年比(1.38±0.49)次,年,t=8.74,P＜0.05],气流阻塞程度差异无统计学意义[FEV1/预计值(39.82±10.95)%比(37.11±12.24)%,t=1.00,P＞0.05].多元线性回归模型显示,RDQ分数是COPD急性加重次数一种可能的预测因子(R2a=0.39,t=6.98,P＜0.05).结论 GERD可能与COPD急性加重次数有关.
目的 探討胃食管反流病(GERD)對慢性阻塞性肺疾病(COPD)急性加重的影響.方法 納入本研究患者均確診為COPD,均完成反流性疾病診斷問捲(RDQ),依據RDQ結果 分為GERD組(38例)和非GERD組(36例),比較兩組患者的臨床資料及每年COPD急性加重次數等.結果 與非GERD組比較,GERD組每年COPD急性加重次數增多[(2.68±0.77)次,年比(1.38±0.49)次,年,t=8.74,P＜0.05],氣流阻塞程度差異無統計學意義[FEV1/預計值(39.82±10.95)%比(37.11±12.24)%,t=1.00,P＞0.05].多元線性迴歸模型顯示,RDQ分數是COPD急性加重次數一種可能的預測因子(R2a=0.39,t=6.98,P＜0.05).結論 GERD可能與COPD急性加重次數有關.
목적 탐토위식관반류병(GERD)대만성조새성폐질병(COPD)급성가중적영향.방법 납입본연구환자균학진위COPD,균완성반류성질병진단문권(RDQ),의거RDQ결과 분위GERD조(38례)화비GERD조(36례),비교량조환자적림상자료급매년COPD급성가중차수등.결과 여비GERD조비교,GERD조매년COPD급성가중차수증다[(2.68±0.77)차,년비(1.38±0.49)차,년,t=8.74,P＜0.05],기류조새정도차이무통계학의의[FEV1/예계치(39.82±10.95)%비(37.11±12.24)%,t=1.00,P＞0.05].다원선성회귀모형현시,RDQ분수시COPD급성가중차수일충가능적예측인자(R2a=0.39,t=6.98,P＜0.05).결론 GERD가능여COPD급성가중차수유관.
Objective To evaluate the effect of gastroesophageal reflux disease(GERD)on exacerbations of chronic obstructive pulmonary disease(COPD).Methods All of 74 patients with COPD accomplishing the reflux diagnostic questionnaire(RDQ)were.divided into GERD group(n=38)and non-GERD group(n=36)according the scores of RDQ.The clinical data including the frequency of exacerbations of COPD were compared between the two groups.Results The frequency of exacerbations of COPD was significantly higher in GERD group compared with that in non-GERD group[(2.68±0.77)times/year vs (1.38±0.49)times/year,t=8.74,P＜0.05].The mean FEV;percentage was similar in the two groups [(39.82 4-10.95)%vs(37.11±12.24)%,t=1.00,P＞0.05].The score of RDQ was probably as a factor of predicting the frequency of exacerbations of COPD(R2a=o.39,t=6.98,P＜0.05).Conclusion The presence of GERD appears to be associated with increased exacerbations of COPD.
