中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2010年
1期
27-29
,共3页
心力衰竭%充血性%利钠肽%脑
心力衰竭%充血性%利鈉肽%腦
심력쇠갈%충혈성%리납태%뇌
Heart failure%congestive%Natriuretic peptide%brain
目的 探讨老年心力衰竭患者血浆脑钠肽(BNP)和N末端B型钠尿肽(NT-proBNP)水平与心力衰竭严重程度、左心室功能等因素的关系,以及肾功能对BNP和NT-proBNP值的影响.方法采用免疫荧光分析法测定106例住院心力衰竭患者BNP水平,采用电化学发光免疫分析法测定48例住院心力衰竭患者NT-proBNP水平.均用心脏彩色多普勒超声诊断仪测定左心室收缩功能,心力衰竭按纽约分级(NYHA). 结果 BNP≤400 ng/L和>400 ng/L患者,左心射血分数(EF)值<45.0%者分别为16.4%和46.8%(χ~2=13.93,P=0.001);心脏彩超A峰、E峰流速比值(E/A)<1者分别为62.3%和40.4%,(χ~2-22.19,P=0.024);肌酐>107 μmol/L者分别为13.1%和38.3%(χ~2=11.31,P=0.002).NT-proBNP≤1800 ng/L和>1800 ng/L患者,EF值<45%者分别为25.0%和58.3%,(χ~2=10.00,P=0.019);E/A≤1者分别为70.1%和20.8%;肌酐>107μmol/L分别为20.8%,和50.0%(χ~2=8.50,P=0.035). 结论 老年心力衰竭患者血浆BNP及NT-proBNP水平随着心力衰竭严重程度的增加而升高,并能较好反映左室功能;肾脏功能对BNP及NT-proBNP水均有影响.
目的 探討老年心力衰竭患者血漿腦鈉肽(BNP)和N末耑B型鈉尿肽(NT-proBNP)水平與心力衰竭嚴重程度、左心室功能等因素的關繫,以及腎功能對BNP和NT-proBNP值的影響.方法採用免疫熒光分析法測定106例住院心力衰竭患者BNP水平,採用電化學髮光免疫分析法測定48例住院心力衰竭患者NT-proBNP水平.均用心髒綵色多普勒超聲診斷儀測定左心室收縮功能,心力衰竭按紐約分級(NYHA). 結果 BNP≤400 ng/L和>400 ng/L患者,左心射血分數(EF)值<45.0%者分彆為16.4%和46.8%(χ~2=13.93,P=0.001);心髒綵超A峰、E峰流速比值(E/A)<1者分彆為62.3%和40.4%,(χ~2-22.19,P=0.024);肌酐>107 μmol/L者分彆為13.1%和38.3%(χ~2=11.31,P=0.002).NT-proBNP≤1800 ng/L和>1800 ng/L患者,EF值<45%者分彆為25.0%和58.3%,(χ~2=10.00,P=0.019);E/A≤1者分彆為70.1%和20.8%;肌酐>107μmol/L分彆為20.8%,和50.0%(χ~2=8.50,P=0.035). 結論 老年心力衰竭患者血漿BNP及NT-proBNP水平隨著心力衰竭嚴重程度的增加而升高,併能較好反映左室功能;腎髒功能對BNP及NT-proBNP水均有影響.
목적 탐토노년심력쇠갈환자혈장뇌납태(BNP)화N말단B형납뇨태(NT-proBNP)수평여심력쇠갈엄중정도、좌심실공능등인소적관계,이급신공능대BNP화NT-proBNP치적영향.방법채용면역형광분석법측정106례주원심력쇠갈환자BNP수평,채용전화학발광면역분석법측정48례주원심력쇠갈환자NT-proBNP수평.균용심장채색다보륵초성진단의측정좌심실수축공능,심력쇠갈안뉴약분급(NYHA). 결과 BNP≤400 ng/L화>400 ng/L환자,좌심사혈분수(EF)치<45.0%자분별위16.4%화46.8%(χ~2=13.93,P=0.001);심장채초A봉、E봉류속비치(E/A)<1자분별위62.3%화40.4%,(χ~2-22.19,P=0.024);기항>107 μmol/L자분별위13.1%화38.3%(χ~2=11.31,P=0.002).NT-proBNP≤1800 ng/L화>1800 ng/L환자,EF치<45%자분별위25.0%화58.3%,(χ~2=10.00,P=0.019);E/A≤1자분별위70.1%화20.8%;기항>107μmol/L분별위20.8%,화50.0%(χ~2=8.50,P=0.035). 결론 노년심력쇠갈환자혈장BNP급NT-proBNP수평수착심력쇠갈엄중정도적증가이승고,병능교호반영좌실공능;신장공능대BNP급NT-proBNP수균유영향.
Objective To investigate the relationship of plasma brain natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels with the severity of heart dysfunction in elderly patients with heart failure. Methods BNP levels were measured by immunofluorescence in 106 hospitalized patients with heart failure, while NT-proBNP levels were measured by electrochemiluminescence immunoassay in 48 patients. The severity of heart dysfunction was determined by NYHA classification. The left ventricular ejection fraction (LVEF) measured by Color Doppler Ultrasound was used to show the left ventricular systolic function. Results In patients with BNP≤400 ng/L versus BNP>400 ng/L, the rates of LVEF≤45% were 16.4% versus 46.8% (χ~2= 13. 93, P=0. 001), the rates of E/A<1 were 62.3% versus 40. 4% (χ~2 =22. 19,P = 0.024) and the rates of Cr>107 μmol/L were 13.1% versus 38.3% (χ~2 = 11. 31, P = 0. 002) . In patients with NT-proBNP≤400 ng/L versus NT-proBNP>400 ng/L, the rates of LVEF≤45% were 25. 0% versus 58. 3% (χ~2 = 10. 00,P = 0. 019) and the rates of Cr>107 μmol/L were 20. 8% versus 50.0% (χ~2=8. 50,P = 0. 035). Conclusions BNP or NT-proBNP levels increase significantly along the deterioration of the heart failure severity, and it may be important to use BNP or NT-proBNP to predict left ventricular function.
