CAJ | 학술논문

2例均为发生于面部的单发结节,光滑,粉红色,缓慢增大.组织病理:真皮中不规则的上皮细胞小叶,边缘由基底样细胞呈栅栏状排列,团块中心由透明细胞构成,小叶中及间质中可见大量的小淋巴细胞浸润.免疫组化:淋巴细胞以CD3阳性为主,少量的CD20阳性细胞,上皮团块及周围间质中较多的S-100+CD1a+树突细胞,细胞角蛋白7、细胞角蛋白20、癌胚抗原均为阴性,1例团块中央少量细胞上皮膜抗原和CD30表达.根据组织病理和免疫组化结果,明确为皮肤淋巴腺瘤,其主要的浸润细胞是CD3阳性淋巴细胞.
2례균위발생우면부적단발결절,광활,분홍색,완만증대.조직병리:진피중불규칙적상피세포소협,변연유기저양세포정책란상배렬,단괴중심유투명세포구성,소협중급간질중가견대량적소림파세포침윤.면역조화:림파세포이CD3양성위주,소량적CD20양성세포,상피단괴급주위간질중교다적S-100+CD1a+수돌세포,세포각단백7、세포각단백20、암배항원균위음성,1례단괴중앙소량세포상피막항원화CD30표체.근거조직병리화면역조화결과,명학위피부림파선류,기주요적침윤세포시CD3양성림파세포.
The histological and immunohistological features of two cases of cutaneous lymphadenoma was studied. A single, erythematous nodule with smooth surface developed on the face of both patients. The lesion slowly progressed. Histology revealed irregular epithelial lobules in the dermis which showed a peripheral palisaded border of basaioid-like cells as well as a center composed of clear cells. Some epithelial lobules and surrounding stroma were infiltrated by numerous small lymphocytes. Immunohistological study showed that the lymphocytic infiltration was predominantly composed of T cells (CD3 positive) along with a small number of B cells (CD20 positive). Within epithelial lobules and surrounded stroma, there were numerous dendritic cells that were positive for S-100 and CDia but negative for cytokeratin 7, cytokeratin 20 or carcino-embryonic antigen. In the center of epithelial lobules in one case, a few cells positive for epithe-lial membrane antigen and CD30 was observed. The diagnosis of cutaneous lymphadenoma was made according to the pathological and immunohistochemical findings, and the infiltration was predominated by CD3-positive lymphocytes in this uncommon epithelial neoplasm.