CAJ | 학술논문

目的研究复方芦荟胶囊中汞的生物利用性及配伍药物对汞生物利用性的影响,以便认识复方芦荟胶囊中汞对人体的健康风险.方法用L8(27)正交表设计实验,体外消化透析法取得汞溶出率及生物可接受率数据.结果复方芦荟胶囊中汞含量为(11.7±0.4)%(P=0.95);复方芦荟胶囊在胃模拟环境中汞溶出率为(1.36±0.06)%(P=0.95),肠模拟环境下生物可接受率为(0.46±0.03)%(P=0.95);芦荟很显著抑制了朱砂中汞的溶出率(P=0.95),芦荟使朱砂中汞生物可接受率显著降低(P=0.90);其他配伍药物及药物交互作用对汞生物利用性不显著.结论复方芦荟胶囊中汞含量高,生物可接受率低,长期服用会存在一定的潜在健康风险;复方芦荟胶囊配伍时可适当增大芦荟用量以降低其汞的生物利用性.
목적 연구복방호회효낭중홍적생물이용성급배오약물대홍생물이용성적영향,이편인식복방호회효낭중홍대인체적건강풍험.방법 용L8(27)정교표설계실험,체외소화투석법취득홍용출솔급생물가접수솔수거.결과 복방호회효낭중홍함량위(11.7±0.4)%(P=0.95);복방호회효낭재위모의배경중홍용출솔위(1.36±0.06)%(P=0.95),장모의배경하생물가접수솔위(0.46±0.03)%(P=0.95);호회흔현저억제료주사중홍적용출솔(P=0.95),호회사주사중홍생물가접수솔현저강저(P=0.90);기타배오약물급약물교호작용대홍생물이용성불현저.결론 복방호회효낭중홍함량고,생물가접수솔저,장기복용회존재일정적잠재건강풍험;복방호회효낭배오시가괄당증대호회용량이강저기홍적생물이용성.
Objective To study the bioaccessibility of mercury from Fufang Luhui Capsule,and to study the influence of different compatibility on the bioavailability of mercury. Methods Eight solutions with cinnabar were prepared using an in vitro dialysis digestion method and were analysed by L8(27)orthogonal design and the contents of mercury were determined by CV-AFS. Results The content of mercury in Fufang Luhui Capsule was (11.7±0.4)%(P=0.95). The experimental results indicated that mercury dissolution rate from Fufang Luhui capsule was (1.36±0.06)%(P=0.95),and the bioaccessibility was (0.46±0.03)%(P=0.95). As a main component of Fufang Luhui Capsule, aloe inhibited the dissolution rate of mercury in cinnabar very significantly(P=0.95), and aloe significantly reduced the bioaccessibility of mercury in cinnabar(P=0.90). Influences of the compatibility of other drugs and drug interactions was insignificant.Conclusion The content of mercury in Fufang Luhui Capsule is high, its bioavailibility is low, and there are still some medicinal potential health risks for long-term intake.Aloe significantly influence its bioavailability, so properly increasing the content of aloe can reduce its bioaccessibility.