临床与实验病理学杂志
臨床與實驗病理學雜誌
림상여실험병이학잡지
CHINESE JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
2010年
1期
40-45
,共6页
蔡俊娜%卿松%成宇帆%杨文涛%王坚
蔡俊娜%卿鬆%成宇帆%楊文濤%王堅
채준나%경송%성우범%양문도%왕견
乳腺肿瘤%非典型性血管病变%放射疗法/副作用%放疗后血管肉瘤
乳腺腫瘤%非典型性血管病變%放射療法/副作用%放療後血管肉瘤
유선종류%비전형성혈관병변%방사요법/부작용%방료후혈관육류
breast neoplasms%atypical vascular lesions%radiotherapy/adverce effects%post-radiation angiosarcoma
目的 探讨研究乳腺癌保乳手术后和放疗后所发生的非典型性血管病变(atypical vascular lesions,AVLs)的临床病理学特点及与血管肉瘤的关系.方法 对1例AVLs的临床资料、组织学形态和免疫表型进行分析,并复习相关文献.结果 患者为57岁女性,因右乳癌接受保乳手术,术后辅助放疗.3年多后于右乳外上瘢痕旁见大小不一的发红皮疹,呈放射状向乳头排列.临床上考虑为右乳癌保乳术后右胸壁复发结节.对皮疹行细针穿刺未见肿瘤细胞.对皮疹的活检显示,病变主要位于真皮浅层,由聚集成簇、相互贯通的薄壁脉管组成,管腔内多无红细胞,内皮细胞也无明显的异型性.局灶区域可见少量脉管向真皮中层内穿插性生长.免疫组化标记显示内皮细胞主要表达CD31,部分表达CD34和D2-40,脉管周无α-SMA阳性的周皮细胞.回顾性复习乳腺癌切片显示为浸润性微乳头状癌.结论 AVLs是一种与乳腺保乳癌术后放疗相关的血管增生性病变,是乳腺癌保乳术后放疗性血管肉瘤的前驱性病变.熟悉AVLs的临床病理学特点不仅对病理医师,而且对临床医生也有积极的意义.
目的 探討研究乳腺癌保乳手術後和放療後所髮生的非典型性血管病變(atypical vascular lesions,AVLs)的臨床病理學特點及與血管肉瘤的關繫.方法 對1例AVLs的臨床資料、組織學形態和免疫錶型進行分析,併複習相關文獻.結果 患者為57歲女性,因右乳癌接受保乳手術,術後輔助放療.3年多後于右乳外上瘢痕徬見大小不一的髮紅皮疹,呈放射狀嚮乳頭排列.臨床上攷慮為右乳癌保乳術後右胸壁複髮結節.對皮疹行細針穿刺未見腫瘤細胞.對皮疹的活檢顯示,病變主要位于真皮淺層,由聚集成簇、相互貫通的薄壁脈管組成,管腔內多無紅細胞,內皮細胞也無明顯的異型性.跼竈區域可見少量脈管嚮真皮中層內穿插性生長.免疫組化標記顯示內皮細胞主要錶達CD31,部分錶達CD34和D2-40,脈管週無α-SMA暘性的週皮細胞.迴顧性複習乳腺癌切片顯示為浸潤性微乳頭狀癌.結論 AVLs是一種與乳腺保乳癌術後放療相關的血管增生性病變,是乳腺癌保乳術後放療性血管肉瘤的前驅性病變.熟悉AVLs的臨床病理學特點不僅對病理醫師,而且對臨床醫生也有積極的意義.
목적 탐토연구유선암보유수술후화방료후소발생적비전형성혈관병변(atypical vascular lesions,AVLs)적림상병이학특점급여혈관육류적관계.방법 대1례AVLs적림상자료、조직학형태화면역표형진행분석,병복습상관문헌.결과 환자위57세녀성,인우유암접수보유수술,술후보조방료.3년다후우우유외상반흔방견대소불일적발홍피진,정방사상향유두배렬.림상상고필위우유암보유술후우흉벽복발결절.대피진행세침천자미견종류세포.대피진적활검현시,병변주요위우진피천층,유취집성족、상호관통적박벽맥관조성,관강내다무홍세포,내피세포야무명현적이형성.국조구역가견소량맥관향진피중층내천삽성생장.면역조화표기현시내피세포주요표체CD31,부분표체CD34화D2-40,맥관주무α-SMA양성적주피세포.회고성복습유선암절편현시위침윤성미유두상암.결론 AVLs시일충여유선보유암술후방료상관적혈관증생성병변,시유선암보유술후방료성혈관육류적전구성병변.숙실AVLs적림상병이학특점불부대병리의사,이차대림상의생야유적겁적의의.
Purpose To describe the clinical and pathological features of atypical vascular lesions (AVLs) after conservative surgery and radiation of the breast cancer,and to discuss the association with post-radiation angiosarcoma.Methods The clinical and pathological features in one case of AVLs was evaluated.The literatures were reviewed.Results The patient is a 57-yeAR~-old female who underwent a conservative surgery of the right breast because of a carcinoma.She received standard dose of radiation as adjuvant therapy.Three years later, multiple erythematous plaques developed around the former scar, which radiated to the nipple.Clinically,the plaques were considered as relapses of the carcinoma.However, fine needle aspiration gave negative results.Biopsy of one large plague revealed a circumscribed vascular lesion confined to the superficial dermis.It was composed of thin-walled anastomosing lymphatic vessels lined by attenuated endothelial cells.In focal areas, the vessels extended to the mid-dermis.Immunohistochemically, the endothelial cells were positive for CD31, CD34 and D2-40,with absent of α-SMA positive pericytes.Review of the breast tumor sections showed an invasive micropapillary carcinoma.Conclusions AVLs is a rare vascular lesion related with conservative surgery and post-radiation therapy of the breast.AVLs may represent as a precursor of breast angiosarcoma.Being familiar with the clinicopathologic characteristics of AVLs is important not only for the pathologists but also for the clinicians.