CAJ | 학술논문

目的探讨辛伐他汀治疗不稳定型心绞痛(UAP)的临床效果.方法将91例UAP患者随机分为对照组37例和观察组54例,观察组在常规治疗的基础上,给予辛伐他汀15～20mg/d,每晚1次,疗程4个月.对照组给予脂必妥1.05g,3次/d,口服.用药前、后分别查血脂、肝肾功能、心肌酶、心电图,记录心血管事件发生情况.结果 16周后观察组TC、TG、LDL-C较治疗前明显下降(P<0.05),HDL-C明显升高(P<0.05),对照组治疗前后血脂比较差异无显著性(P>0.05).观察组心血管事件发生率明显低,与对照组相比具有统计学意义(P<0.05).结论应用辛伐他汀能改善UAP患者的临床症状,副作用少,使用方便安全,能有效地降低心血管事件发生率,值得临床推广.
목적 탐토신벌타정치료불은정형심교통(UAP)적림상효과.방법 장91례UAP환자수궤분위대조조37례화관찰조54례,관찰조재상규치료적기출상,급여신벌타정15～20mg/d,매만1차,료정4개월.대조조급여지필타1.05g,3차/d,구복.용약전、후분별사혈지、간신공능、심기매、심전도,기록심혈관사건발생정황.결과 16주후관찰조TC、TG、LDL-C교치료전명현하강(P<0.05),HDL-C명현승고(P<0.05),대조조치료전후혈지비교차이무현저성(P>0.05).관찰조심혈관사건발생솔명현저,여대조조상비구유통계학의의(P<0.05).결론 응용신벌타정능개선UAP환자적림상증상,부작용소,사용방편안전,능유효지강저심혈관사건발생솔,치득림상추엄.
Objective To approach the clinical effect of the treatment to the unstable angina pectoris(UAP)with Simvastatin.Methods 91 cases of patients with UAP were randomly divided into control group with 37 cases and observation group with 54 cases.Observation group were observed in the conventional treatment group,based on the given simvastatin 15～20mg/d,one time per night,and kept 4months for the course of treament.In the control group Zhinbiticose were given 1.05g,three times/d,using as oral.the blood lipid,liver and kidney function enzymes,ECG can be checked before and after the medication,and the records of the occurrence of cardiovascular events can be took.Results 16 weeks after treatment in the observation group,TC,TG,LDL-C were decreased significantly than that before the treatment(P<0.05).HDL-C were significantly increased(P<0.05).In the control group before and after the treatment,there was no significant difference on the lipids(P>0.05).Cardiovascular events in the observation group were significantly lower compared with the control group with statistical significance(P<0.05).Conclusions Simvastatin used for patients with UAP can improve the clinical symptoms,it had fewer side effects,it was easy to use the security,and reduced the incidence of cardiovascular events,was worthy to be popularized.