中华急诊医学杂志
中華急診醫學雜誌
중화급진의학잡지
CHINESE JOURNAL OF EMERGENCY MEDICINE
2011年
11期
1179-1182
,共4页
高迁移率蛋白-1%中性粒细胞激活肽-78%脑损伤%脑水肿
高遷移率蛋白-1%中性粒細胞激活肽-78%腦損傷%腦水腫
고천이솔단백-1%중성립세포격활태-78%뇌손상%뇌수종
High mobility group box-1%Epithelial neutrophil-activing%Peptide-78%Brain injuries%Brain edema
目的 研究急性颅脑损伤后血中高迁移率蛋白-1(HMGB1)和中性粒细胞激活肽-78(ENA-78)的动态变化及其与继发性脑水肿的关系.方法 采用酶联免疫吸附法(ELISA)检测HMGB1和ENA-78血中含量,回顾性分析110例急性颅脑损伤住院患者伤后12 h内、伤后第3,5d血中HMGB1和ENA-78含量,采用t检验并结合临床表现、影像学检查及格拉斯哥预后评分(GOS)进行比较分析.结果 急性颅脑损伤患者伤后早期12h内血中HMGB1和ENA-78含量随着格拉斯哥昏迷评分(GCS)下降均有不同程度的升高.颅脑损伤越严重,HMGB1和ENA-78升高越明显,脑水肿程度越重,并且脑水肿高峰持续时间越长(P＜0.01).颅脑损伤早期血中HMGB1和ENA-78含量与脑水肿严重程度(r=0.69,0.62,P＜0.01)和脑水肿高峰持续时间呈正相关(r =0.70,0.65,P＜0.01).此外,不同GOS组之间HMGB1和ENA-78差异亦有统计学意义,其中预后不良组血中HMGB1和ENA-78含量在伤后5d内持续升高,而且显著高于预后良好组和健康对照组(P＜0.01或P＜0.05).同时急性颅脑损伤后血中HMGB1与ENA-78的含量呈正相关(r=0.68,P＜0.01).结论 急性颅脑损伤后血中HMGB1和ENA-78的变化与继发性脑水肿存在一定的相关性.
目的 研究急性顱腦損傷後血中高遷移率蛋白-1(HMGB1)和中性粒細胞激活肽-78(ENA-78)的動態變化及其與繼髮性腦水腫的關繫.方法 採用酶聯免疫吸附法(ELISA)檢測HMGB1和ENA-78血中含量,迴顧性分析110例急性顱腦損傷住院患者傷後12 h內、傷後第3,5d血中HMGB1和ENA-78含量,採用t檢驗併結閤臨床錶現、影像學檢查及格拉斯哥預後評分(GOS)進行比較分析.結果 急性顱腦損傷患者傷後早期12h內血中HMGB1和ENA-78含量隨著格拉斯哥昏迷評分(GCS)下降均有不同程度的升高.顱腦損傷越嚴重,HMGB1和ENA-78升高越明顯,腦水腫程度越重,併且腦水腫高峰持續時間越長(P＜0.01).顱腦損傷早期血中HMGB1和ENA-78含量與腦水腫嚴重程度(r=0.69,0.62,P＜0.01)和腦水腫高峰持續時間呈正相關(r =0.70,0.65,P＜0.01).此外,不同GOS組之間HMGB1和ENA-78差異亦有統計學意義,其中預後不良組血中HMGB1和ENA-78含量在傷後5d內持續升高,而且顯著高于預後良好組和健康對照組(P＜0.01或P＜0.05).同時急性顱腦損傷後血中HMGB1與ENA-78的含量呈正相關(r=0.68,P＜0.01).結論 急性顱腦損傷後血中HMGB1和ENA-78的變化與繼髮性腦水腫存在一定的相關性.
목적 연구급성로뇌손상후혈중고천이솔단백-1(HMGB1)화중성립세포격활태-78(ENA-78)적동태변화급기여계발성뇌수종적관계.방법 채용매련면역흡부법(ELISA)검측HMGB1화ENA-78혈중함량,회고성분석110례급성로뇌손상주원환자상후12 h내、상후제3,5d혈중HMGB1화ENA-78함량,채용t검험병결합림상표현、영상학검사급격랍사가예후평분(GOS)진행비교분석.결과 급성로뇌손상환자상후조기12h내혈중HMGB1화ENA-78함량수착격랍사가혼미평분(GCS)하강균유불동정도적승고.로뇌손상월엄중,HMGB1화ENA-78승고월명현,뇌수종정도월중,병차뇌수종고봉지속시간월장(P＜0.01).로뇌손상조기혈중HMGB1화ENA-78함량여뇌수종엄중정도(r=0.69,0.62,P＜0.01)화뇌수종고봉지속시간정정상관(r =0.70,0.65,P＜0.01).차외,불동GOS조지간HMGB1화ENA-78차이역유통계학의의,기중예후불량조혈중HMGB1화ENA-78함량재상후5d내지속승고,이차현저고우예후량호조화건강대조조(P＜0.01혹P＜0.05).동시급성로뇌손상후혈중HMGB1여ENA-78적함량정정상관(r=0.68,P＜0.01).결론 급성로뇌손상후혈중HMGB1화ENA-78적변화여계발성뇌수종존재일정적상관성.
Objective To investigate the dynamic changes of serum high mobility group box-1 (HMGB1)and epithelial neutrophil-activing peptide-78(ENA-78)associated with secondary brain edema in patients following acute brain injury.Methods The serum HMGB1 and ENA-78 in 110 patients with acute brain injury were determined by using enzyme-linked immunosorbent assay(ELISA)12 hours,3 days and the 5 days after acute brain injury.The outcomes were analyzed by t-test and estimated well with clinical symptoms,imaging data and Glasgow Outcome Scale(GOS)in combination of.Results The levels of HMGB1 and ENA-78 increased significantly with lowering the score of GCS 12 hours after acute brain injury.The more severity of acute brain injury resulted in more production of HMGB1 and ENA-78 and longer period of persisted and peaked brain edema(all P ＜0.01).HMGB1 levels had positive correlation with severity and persistence of brain edema(r =0.69,P ＜0.01 and r =0.70,P ＜0.01).ENA-78 levels had positive correlation with severity and persistence of brain edema(r =0.62,P ＜ 0.01 and r =0.65,P ＜ 0.01).Furthermore,there were statistical differences in HMGB1 and ENA-78 levels between different GOS groups.Compared with good outcome group and normal control group,the HMGB1 and ENA-78 levels in poor outcome group persistently increased and were higher within 5 days after brain injury(P ＜ 0.01 or P ＜0.05).There was a correlation between serum HMGB1 and ENA-78 levels in patients with acute brain injuries(r =0.68,P ＜ 0.01).Conclusions The changes of serum HMGB1 and ENA-78 levels were closely associated with secondary brain edema in patients following acute brain injury.
