中国临床实用医学
中國臨床實用醫學
중국림상실용의학
CHINA CLINICAL PRACTICAL MEDICINE
2010年
2期
13-14
,共2页
心力衰竭%瘦素%胰岛素抵抗
心力衰竭%瘦素%胰島素牴抗
심력쇠갈%수소%이도소저항
Heart failure%Leptin%Insulin resistance
目的 探讨心力衰竭(简称心衰)患者血清瘦素水平、胰岛素抵抗(IR)与心衰严重程度的关系.方法 选择心衰患者90例,按NYHA心功能分级分为三组(心功能Ⅱ级、心功能Ⅲ级、心功能Ⅳ级组),每组30例.健康对照组60例,放免法测定血清瘦素、空腹胰岛素(FINS)水平,全自动生化分析仪测定空腹血糖(FBG)水平,并计算胰岛素抵抗指数(HOMA-IR).结果 心衰组血清瘦素、胰岛素抵抗水平较对照组显著增高(P＜0.01);心衰组瘦素,胰岛素抵抗水平按NYHA分级分别为:NYHA分级Ⅱ级为(8.17±4.39)ng/L、1.98±0.96,NYHA分级Ⅲ级为(11.28 ±4.95)ng/L、3.48±1.26,NYHA分级Ⅳ级为(14.29±5.85)ng/L、5.32±1.52,差异有统计学意义(P＜0.05).结论 心衰患者血清瘦素、胰岛素抵抗水平显著升高,并与心衰严重程度存在一定相关性,可以较准确地评价患者心衰的严重程度.
目的 探討心力衰竭(簡稱心衰)患者血清瘦素水平、胰島素牴抗(IR)與心衰嚴重程度的關繫.方法 選擇心衰患者90例,按NYHA心功能分級分為三組(心功能Ⅱ級、心功能Ⅲ級、心功能Ⅳ級組),每組30例.健康對照組60例,放免法測定血清瘦素、空腹胰島素(FINS)水平,全自動生化分析儀測定空腹血糖(FBG)水平,併計算胰島素牴抗指數(HOMA-IR).結果 心衰組血清瘦素、胰島素牴抗水平較對照組顯著增高(P＜0.01);心衰組瘦素,胰島素牴抗水平按NYHA分級分彆為:NYHA分級Ⅱ級為(8.17±4.39)ng/L、1.98±0.96,NYHA分級Ⅲ級為(11.28 ±4.95)ng/L、3.48±1.26,NYHA分級Ⅳ級為(14.29±5.85)ng/L、5.32±1.52,差異有統計學意義(P＜0.05).結論 心衰患者血清瘦素、胰島素牴抗水平顯著升高,併與心衰嚴重程度存在一定相關性,可以較準確地評價患者心衰的嚴重程度.
목적 탐토심력쇠갈(간칭심쇠)환자혈청수소수평、이도소저항(IR)여심쇠엄중정도적관계.방법 선택심쇠환자90례,안NYHA심공능분급분위삼조(심공능Ⅱ급、심공능Ⅲ급、심공능Ⅳ급조),매조30례.건강대조조60례,방면법측정혈청수소、공복이도소(FINS)수평,전자동생화분석의측정공복혈당(FBG)수평,병계산이도소저항지수(HOMA-IR).결과 심쇠조혈청수소、이도소저항수평교대조조현저증고(P＜0.01);심쇠조수소,이도소저항수평안NYHA분급분별위:NYHA분급Ⅱ급위(8.17±4.39)ng/L、1.98±0.96,NYHA분급Ⅲ급위(11.28 ±4.95)ng/L、3.48±1.26,NYHA분급Ⅳ급위(14.29±5.85)ng/L、5.32±1.52,차이유통계학의의(P＜0.05).결론 심쇠환자혈청수소、이도소저항수평현저승고,병여심쇠엄중정도존재일정상관성,가이교준학지평개환자심쇠적엄중정도.
Objective To explore the relations between serum leptin and insulin resistance (IR)and the degree of heart failure. Methods 150subjects were selected, including 60 healthy controls and 90 patients with heart failure. We determined the concentration of fasting insulin (FINS)and leptin in serum in these patients by radioimmunoassay. Insulin resistance index was calculated to evaluate insulin resistance degree. Results The concentrations of leptin and HOMA-IR in heart failure cases were significant higher than those in the control group (P ＜ 0.01 )and it was also showed that the more severe the heart failure, the higher the leptin and HOMAIR[(8.17 ± 4.39) ng/L, ( 1.98 ± 0.96) in class Ⅱ, ( 11.28 ± 4.95) ng/L, (3.48 ± 1.26) in class Ⅲ, ( 14.29± 5.85 ) ng/L, (5.32 ± 1.52) in class Ⅳ, ( P ＜ 0.05 )]. Conclusion The serum leptin concentrations and degree of insulin resistance were significantly higher in patients with heart failure, they are correlative with the degree of heart failure, and may evaluate the severe degree of heart failure.
