中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2009年
12期
2141-2143
,共3页
糖尿病2型%胰岛素泵%血糖漂移%动态血糖监测系统
糖尿病2型%胰島素泵%血糖漂移%動態血糖鑑測繫統
당뇨병2형%이도소빙%혈당표이%동태혈당감측계통
Type 2 diabetes mellitus%Continuous subcutaneous insulin infusion%Glycemic excursion%Continuous glucose monitoring system
目的 观察新诊断的2型糖尿病(T2DM)患者胰岛素泵治疗前后血糖漂移变化特征,评估胰岛素泵强化控制血糖的疗效.方法 选取新诊断的T2DM患者38例,随机分为胰岛素泵治疗组(CSⅡ)18例,胰岛素多次皮下注射组(MSⅡ)20例,对其治疗前后采用动态血糖监测系统(CGMS)进行连续3 d的血糖监测,进行自身前后对照和组间对照分析.结果 两组患者经2周治疗后糖代谢紊乱明显缓解,38例治疗前后全天平均血糖(MBG)、日内血糖平均波动幅度(MAGE)、日间血糖平均绝对差(MODD)比较差异均有统计学意义(P＜0.001);治疗后血糖＞7.8 mmol/L和＞11.1 mmol/L所占日内时间百分比与治疗前比较均有显著降低(P＜0.001);治疗后餐前及餐后各时段的平均血糖水平亦显著下降(P＜0.05,P＜0.01).上述各项血糖参数CSⅡ组均优于MSⅡ组(P＜0.01,P＜0.001).结论 动态血糖监测能评估血糖漂移变化特征,胰岛素泵为强化控制血糖的有效方法 .
目的 觀察新診斷的2型糖尿病(T2DM)患者胰島素泵治療前後血糖漂移變化特徵,評估胰島素泵彊化控製血糖的療效.方法 選取新診斷的T2DM患者38例,隨機分為胰島素泵治療組(CSⅡ)18例,胰島素多次皮下註射組(MSⅡ)20例,對其治療前後採用動態血糖鑑測繫統(CGMS)進行連續3 d的血糖鑑測,進行自身前後對照和組間對照分析.結果 兩組患者經2週治療後糖代謝紊亂明顯緩解,38例治療前後全天平均血糖(MBG)、日內血糖平均波動幅度(MAGE)、日間血糖平均絕對差(MODD)比較差異均有統計學意義(P＜0.001);治療後血糖＞7.8 mmol/L和＞11.1 mmol/L所佔日內時間百分比與治療前比較均有顯著降低(P＜0.001);治療後餐前及餐後各時段的平均血糖水平亦顯著下降(P＜0.05,P＜0.01).上述各項血糖參數CSⅡ組均優于MSⅡ組(P＜0.01,P＜0.001).結論 動態血糖鑑測能評估血糖漂移變化特徵,胰島素泵為彊化控製血糖的有效方法 .
목적 관찰신진단적2형당뇨병(T2DM)환자이도소빙치료전후혈당표이변화특정,평고이도소빙강화공제혈당적료효.방법 선취신진단적T2DM환자38례,수궤분위이도소빙치료조(CSⅡ)18례,이도소다차피하주사조(MSⅡ)20례,대기치료전후채용동태혈당감측계통(CGMS)진행련속3 d적혈당감측,진행자신전후대조화조간대조분석.결과 량조환자경2주치료후당대사문란명현완해,38례치료전후전천평균혈당(MBG)、일내혈당평균파동폭도(MAGE)、일간혈당평균절대차(MODD)비교차이균유통계학의의(P＜0.001);치료후혈당＞7.8 mmol/L화＞11.1 mmol/L소점일내시간백분비여치료전비교균유현저강저(P＜0.001);치료후찬전급찬후각시단적평균혈당수평역현저하강(P＜0.05,P＜0.01).상술각항혈당삼수CSⅡ조균우우MSⅡ조(P＜0.01,P＜0.001).결론 동태혈당감측능평고혈당표이변화특정,이도소빙위강화공제혈당적유효방법 .
Objective To observe the characteristics of glycemic excursion and to evaluate the therapeutic effects on blood glucose in new dignosed type 2 diabetes mellitus after being given continuous subcutaneous insulin infusion(CS Ⅱ).Methods Thirty-eight new dignosed type 2 diabetes mellitus patients were randomly divided into group CS Ⅱ(n=18) and group many-times subcutaneous insulin infusion(MS Ⅱ,n=20).The blood glucose lasted for three days were monitored by continuous glucose monitoring system(CGMS).Results The abnormal glucose metabolism in two groups were markedly released after two weeks treatment,the mean blood glycemic(MBG),mean amphtude of glycemic excursions(MAGE),means of daily differences(MODD) and the percentage of blood glucose beyond 7.8 mmol/L and 11.1 mmol/L after therapy were all significantly decreased compared with those of before therapy (P＜0.001);the average levels of blood glucose before and after diet were decreased obviously as well(P＜0.05,P＜0.01).All index in group CS Ⅱ were lower than that of group MS Ⅱ (P＜0.01,P＜0.001).Conclusion Continuous glucose monitoring system can assess the changes characteristics of blood glucose effectively,continuous subcutaneous insulin infusion was an effective means of controlling blood glucose.
