CAJ | 학술논문

目的了解网络征集的59例"自疑HIV感染者"流行病学特征和临床表现.方法 "自疑HIV感染者"定义为网络聊天室中自诉具有至少3项类似艾滋病症状者:持续低热、皮疹、淋巴结肿大、乏力、腹泻、体重下降或CD4+T淋巴细胞计数低于正常.通过网络问卷调查,在88例报名者中选择59例做志愿临床检查与实验室检测.结果 59例"自疑HIV感染者"来自22个省(市),男性54例(91.5%),平均年龄34岁(22～53岁).84.7%"自疑HIV感染者"在出现自述"症状"前有过高危性行为."暴露"至"症状出现"之间的时间间隔中位数为15 d(1～365 d).59例"自疑HIV感染者"的HIV抗体、梅毒抗体及嗜异种性小鼠白血病病毒相关病毒(XMRV)检测均为阴性;1例丙型肝炎抗体检测阳性,CD4+T淋巴细胞计数算术均数为707个/μl.59例"自疑HIV感染者"中,有57例(96.6%)参加系统临床检查,40例无明显器质性病变.结论未发现59例"自疑HIV感染者"存在HIV感染证据,也未发现有可以解释其症状的传染性疾病存在.
목적 료해망락정집적59례"자의HIV감염자"류행병학특정화림상표현.방법 "자의HIV감염자"정의위망락료천실중자소구유지소3항유사애자병증상자:지속저열、피진、림파결종대、핍력、복사、체중하강혹CD4+T림파세포계수저우정상.통과망락문권조사,재88례보명자중선택59례주지원림상검사여실험실검측.결과 59례"자의HIV감염자"래자22개성(시),남성54례(91.5%),평균년령34세(22～53세).84.7%"자의HIV감염자"재출현자술"증상"전유과고위성행위."폭로"지"증상출현"지간적시간간격중위수위15 d(1～365 d).59례"자의HIV감염자"적HIV항체、매독항체급기이충성소서백혈병병독상관병독(XMRV)검측균위음성;1례병형간염항체검측양성,CD4+T림파세포계수산술균수위707개/μl.59례"자의HIV감염자"중,유57례(96.6%)삼가계통림상검사,40례무명현기질성병변.결론 미발현59례"자의HIV감염자"존재HIV감염증거,야미발현유가이해석기증상적전염성질병존재.
Objective To describe the epidemiologic characteristics and clinical manifestations of 59 persons recruited via an intemet chat group who complained of AIDS-like symptoms, so as to formulate effective intervention strategies and measures. Methods Case was defined as onset of any three of the following self-reported AIDS-like symptoms in a member of relevant "intemet chat groups": persistent low grade fever, rash, swollen lymph node, fatigue, diarrhea, weight loss and low CD4+T count. We administered an internet-based questionnaire, and invited 59 of the 88 casepersons for voluntary physical examination and laboratory testing. Results The 59 case-persons came from 22 provinces; 54 (91.5 %)were men; the median age was 34 (range: 22-53)years; 84.7% of them had high-risk sexual behaviors before the onset of self-reported symptoms. The median time interval from exposure to onset was 15 d (range: 1-365 d). Blood specimens for all the 59 case-persons were tested negative for HIV and syphilis antibodies. There was also no evidence of Xenotropic murine leukemia virus-related virus infection. One case-person was tested positive for hepatitis C virus antibody. The average CD4'T lymphocyte count was 707/μl. Of the 59 case-persons,57 (96.6%) sought medical care from multiple providers; 40 were diagnosed to have no physical disorders. Conclusion None of the 59 case-persons had any evidence of infection with HIV or any other infectious agents that could explain their self-reported symptoms.