CAJ | 학술논문

探讨2型糖尿病发病机制中内脂素与内皮素及胰岛素抵抗的关系.比较治疗前后内皮素、内脂素等指标.治疗后内脂素水平降低,内皮素与空腹胰岛素、稳态模型评估的胰岛素抵抗指数(HOMA-IR)、稳态模型评估的胰岛β细胞功能(HOMA-β)、内脂素正相关,内脂素与内皮素、HbA1c、空腹胰岛素、HOMA-IR正相关,HOMA-IR是血浆内脂素的独立相关因素.内脂素与内皮素、胰岛索抵抗有关,可能与2型糖尿病及胰岛素抵抗的发病机制密切相关.
탐토2형당뇨병발병궤제중내지소여내피소급이도소저항적관계.비교치료전후내피소、내지소등지표.치료후내지소수평강저,내피소여공복이도소、은태모형평고적이도소저항지수(HOMA-IR)、은태모형평고적이도β세포공능(HOMA-β)、내지소정상관,내지소여내피소、HbA1c、공복이도소、HOMA-IR정상관,HOMA-IR시혈장내지소적독립상관인소.내지소여내피소、이도색저항유관,가능여2형당뇨병급이도소저항적발병궤제밀절상관.
The relationship between visfatin.endothelin, and insulin resistance in the pathogenesis of type 2 diabetes mellitus was explored. Endothelin, visfatin, and other markers were compared. Plasma visfatin was reduced after therapy. Endothelin was positively correlated with fasting insulin, HOMA-IR, HOMA-p, and visfatin. Visfatin was positively correlated with endothelin, HbA1C , fasting insulin, and HOMA-IR. HOMA-IR was an independent related factor in influencing visfatin. The visfatin is related to endothelin and insulin resistance, which may contribute to the pathogenesis of insulin resistance and type 2 diabetes mellitus.