中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2009年
8期
1034-1036
,共3页
王雅平%华鲁纯%蒿汉坤%陈宗秸
王雅平%華魯純%蒿漢坤%陳宗秸
왕아평%화로순%호한곤%진종갈
结直肠肿瘤%hPer2蛋白%病理学,临床
結直腸腫瘤%hPer2蛋白%病理學,臨床
결직장종류%hPer2단백%병이학,림상
Colorectal carcinoma%hPer2 protein%Pathology,clinical
目的 检测hPer2蛋白在人结直肠癌中的表达,探讨其临床意义.方法 取人结直肠癌及癌旁组织各38例,以免疫组织化学方法检测其中hPer2蛋白的表达,并分析其表达与l临床及病理常用指标的关系.结果 在结直肠癌及癌旁正常黏膜细胞中hPer2均有表达,阳性表达率分别为81.6%(31/38)及97.4%(37/38),两者间差异有统计学意义(P<0.05).以癌旁组织为参照,hPer2在癌组织中表达下调者占63.1%(24/38),表达上调者占5.3%(2/38),无明显区别者占31.6%(12/38),其差异有统计学意义(P<0.01).hPer2表达失调与结直肠癌患者年龄≤50岁、肿瘤组织学分级高、浸润深度深、有淋巴结转移、TNM分期晚相关(P<0.05).结论 hPer2在人结直肠癌中表达下调.hPer2表达的失调甚至缺失可能与结直肠癌的生长、浸润、转移相关.
目的 檢測hPer2蛋白在人結直腸癌中的錶達,探討其臨床意義.方法 取人結直腸癌及癌徬組織各38例,以免疫組織化學方法檢測其中hPer2蛋白的錶達,併分析其錶達與l臨床及病理常用指標的關繫.結果 在結直腸癌及癌徬正常黏膜細胞中hPer2均有錶達,暘性錶達率分彆為81.6%(31/38)及97.4%(37/38),兩者間差異有統計學意義(P<0.05).以癌徬組織為參照,hPer2在癌組織中錶達下調者佔63.1%(24/38),錶達上調者佔5.3%(2/38),無明顯區彆者佔31.6%(12/38),其差異有統計學意義(P<0.01).hPer2錶達失調與結直腸癌患者年齡≤50歲、腫瘤組織學分級高、浸潤深度深、有淋巴結轉移、TNM分期晚相關(P<0.05).結論 hPer2在人結直腸癌中錶達下調.hPer2錶達的失調甚至缺失可能與結直腸癌的生長、浸潤、轉移相關.
목적 검측hPer2단백재인결직장암중적표체,탐토기림상의의.방법 취인결직장암급암방조직각38례,이면역조직화학방법검측기중hPer2단백적표체,병분석기표체여l림상급병리상용지표적관계.결과 재결직장암급암방정상점막세포중hPer2균유표체,양성표체솔분별위81.6%(31/38)급97.4%(37/38),량자간차이유통계학의의(P<0.05).이암방조직위삼조,hPer2재암조직중표체하조자점63.1%(24/38),표체상조자점5.3%(2/38),무명현구별자점31.6%(12/38),기차이유통계학의의(P<0.01).hPer2표체실조여결직장암환자년령≤50세、종류조직학분급고、침윤심도심、유림파결전이、TNM분기만상관(P<0.05).결론 hPer2재인결직장암중표체하조.hPer2표체적실조심지결실가능여결직장암적생장、침윤、전이상관.
Objective To detect the expression of a circadian gene, hPer2, in human colorectal carcinoma, and analyze its relation to clinico-pathological data.Methods The expression of hPer2 was detected in 38 paired eolorectal carcinoma tissues and surrounding non-cancerous tissues by immunohistochemical staining.The relationship between hPer2 and several clinicopathological parameters was analyzed.Results hPer2 protein was positively stained in 81.6% (31/38) of colorectal carcinoma tissues and 97.4% (37/38) of surrounding non-cancerous tissues (P < 0.05).Compared with the surrounding non-cancerous tissues, the expression of hPer2 protein was decreased in 24 cases (63.1%), and increased in 2 eases (5.3%) ,while no obvious difference was found in 12 cases (31.6%) (P <0.01).Low expression of hPer2 protein in cancerous cells was correlated with age (≤<50 years) ,pathological differentiation, depth of tumor invasion, lymph nodes metastasis, and TNM stage of coloreetal carcinoma (P < 0.05).Conclusion The expression hPer2 protein was decreased in human colorectal carcinoma.There was a positive correlation between the down-regulation of hPer2 protein with the development, invasion, and metastasis in colorectal carcinoma patients.
