中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2011年
4期
14-16
,共3页
许天蕴%冯龄%陆之瑾%赵秀娥
許天蘊%馮齡%陸之瑾%趙秀娥
허천온%풍령%륙지근%조수아
C反应蛋白%代谢综合征%血管病变
C反應蛋白%代謝綜閤徵%血管病變
C반응단백%대사종합정%혈관병변
C-reactive protein%Metabolic syndrome%Angiopathy
目的 探讨代谢综合征(MS)对2型糖尿病(T2DM)患者血管并发症的影响以及C反应蛋白(CRP)与MS及血管并发症的相关性.方法 选取168例T2DM患者,160例MS患者,所有患者均测血压、身高、体重、腰围、臀围、血糖、糖化血红蛋白(HbA1c)、血脂、CRP,用高敏感B超测颈动脉内膜中层厚度(IMT),眼底摄片了解视网膜病变.结果 ①MS组比T2DM组有更高的冠心病、脑梗死、视网膜病变的发生率,更高的颈动脉IMT,且随着MS组份数的增加而增加.②回归分析显示CRP水平与MS组份数、WHR、空腹血糖(FBG)、收缩压(SBP)呈正相关(β=0.2341,0.201,0.151,0.045;P=0.000,0.001,0.011,0.028).与高密度脂蛋白呈负相关(β=-0.141,P=0.019),颈动脉IMT与MS组份数、T2DM病程、CRP呈正相关(β=0.328,0.197,0.174;P=0.000,0.001,0.008).DR与T2DM病程、CRP、SBP呈正相关(β=0.916,0.160,0.023;P=0.000,0.000,0.026).结论 MS与T2DM患者的血管并发症密切相关,而CRP对MS病情的发展及血管并发症有一定的预测价值.
目的 探討代謝綜閤徵(MS)對2型糖尿病(T2DM)患者血管併髮癥的影響以及C反應蛋白(CRP)與MS及血管併髮癥的相關性.方法 選取168例T2DM患者,160例MS患者,所有患者均測血壓、身高、體重、腰圍、臀圍、血糖、糖化血紅蛋白(HbA1c)、血脂、CRP,用高敏感B超測頸動脈內膜中層厚度(IMT),眼底攝片瞭解視網膜病變.結果 ①MS組比T2DM組有更高的冠心病、腦梗死、視網膜病變的髮生率,更高的頸動脈IMT,且隨著MS組份數的增加而增加.②迴歸分析顯示CRP水平與MS組份數、WHR、空腹血糖(FBG)、收縮壓(SBP)呈正相關(β=0.2341,0.201,0.151,0.045;P=0.000,0.001,0.011,0.028).與高密度脂蛋白呈負相關(β=-0.141,P=0.019),頸動脈IMT與MS組份數、T2DM病程、CRP呈正相關(β=0.328,0.197,0.174;P=0.000,0.001,0.008).DR與T2DM病程、CRP、SBP呈正相關(β=0.916,0.160,0.023;P=0.000,0.000,0.026).結論 MS與T2DM患者的血管併髮癥密切相關,而CRP對MS病情的髮展及血管併髮癥有一定的預測價值.
목적 탐토대사종합정(MS)대2형당뇨병(T2DM)환자혈관병발증적영향이급C반응단백(CRP)여MS급혈관병발증적상관성.방법 선취168례T2DM환자,160례MS환자,소유환자균측혈압、신고、체중、요위、둔위、혈당、당화혈홍단백(HbA1c)、혈지、CRP,용고민감B초측경동맥내막중층후도(IMT),안저섭편료해시망막병변.결과 ①MS조비T2DM조유경고적관심병、뇌경사、시망막병변적발생솔,경고적경동맥IMT,차수착MS조빈수적증가이증가.②회귀분석현시CRP수평여MS조빈수、WHR、공복혈당(FBG)、수축압(SBP)정정상관(β=0.2341,0.201,0.151,0.045;P=0.000,0.001,0.011,0.028).여고밀도지단백정부상관(β=-0.141,P=0.019),경동맥IMT여MS조빈수、T2DM병정、CRP정정상관(β=0.328,0.197,0.174;P=0.000,0.001,0.008).DR여T2DM병정、CRP、SBP정정상관(β=0.916,0.160,0.023;P=0.000,0.000,0.026).결론 MS여T2DM환자적혈관병발증밀절상관,이CRP대MS병정적발전급혈관병발증유일정적예측개치.
Objective To study the effect of aggregation of metabolic syndrome(MS) component on vascular complication in type-2 diabetes mellitus(T2DM) and to study the relationship between high-sensitive C-reactive protein(CRP), MS and vascular complication. Methods One hundred and sixty-eight cases of T2DM and 160 cases of MS were included in this study. All subjects were required to have blood pressure, weight, height, waist circumference and hip circumference measured. Serum CRP, glucose and fasting lipids were tested. Body mass index(BMI) and waist-hip- ratio(WHR) were calculated. Intima-media thickness(IMT) was determined by B mode ultrasonography of high resolution. Non-mydriatic funclus camera screening was carried out in all these patients. diabetic retinopathy (DR) was higher in group MS than in group T2DM. IMT was also higher in group MS than in group T2DM. The higher the number of MS component was, the higher the incidence of coronary artery heart disease, positively correlated with the number of MS component, WHR, fasting plasma glucose and systolic blood pressure(β=0.2341,0.201,0.151,0.045;P=0.000,0.001,0.011,0.028). The level of CRP was negatively correlated with HDL(β=-0.141,P=0.019). IMT was positively correlated with number of MS component, duration of T2DM and CRP (β=0.328,0.197,0.174;P=0.000,0.001,0.008). The incidence of DR was positively correlated with CRP, duration of T2DM and SBP(β=0.916,0.160,0.023;P=0.000,0.000,0.026). Conclusions The aggregation of MS component is closely correlated with vascular complication in T2DM. CRP has some predictive value in the development of MS and vascular complication.
