CAJ | 학술논문

目的了解艾滋病病毒(HIV)感染人群常见的恶性肿瘤类型及患者生存状况.方法以同期医院恶性肿瘤登记为基础,分析HIV合并恶性肿瘤的常见类型;COX回归模型分析HIV合并恶性肿瘤患者的预后.结果该地区HIV合并恶性肿瘤以非霍奇金淋巴瘤(NHL)、子宫颈癌和肝癌常见(占65.1%);非HIV合并恶性肿瘤以肺癌、结肠癌和乳腺癌常见(占34.4%).HIV人群与非HIV人群比较:肿瘤发生时的平均年龄分别为(42.5±8.8)岁和(55.1±13.7)岁(P＜0.05);CD+4T淋巴细胞均数分别是(220.9±142.3)/μl和(554.4±174.3)/μl(P＜0.05).HIV合并恶性肿瘤患者的预后与治疗方法关系密切,还与患者年龄及CD+4T淋巴细胞计数有关.结论中国中部地区HIV合并恶性肿瘤的平均发病年龄在42岁左右;恶性淋巴瘤、子宫颈癌和肝癌是该地区HIV人群最常见的恶性肿瘤;抗肿瘤联合抗HⅣ治疗(ART)能有效改善HIV合并恶性肿瘤患者的预后.
목적 료해애자병병독(HIV)감염인군상견적악성종류류형급환자생존상황.방법 이동기의원악성종류등기위기출,분석HIV합병악성종류적상견류형;COX회귀모형분석HIV합병악성종류환자적예후.결과 해지구HIV합병악성종류이비곽기금림파류(NHL)、자궁경암화간암상견(점65.1%);비HIV합병악성종류이폐암、결장암화유선암상견(점34.4%).HIV인군여비HIV인군비교:종류발생시적평균년령분별위(42.5±8.8)세화(55.1±13.7)세(P＜0.05);CD+4T림파세포균수분별시(220.9±142.3)/μl화(554.4±174.3)/μl(P＜0.05).HIV합병악성종류환자적예후여치료방법관계밀절,환여환자년령급CD+4T림파세포계수유관.결론 중국중부지구HIV합병악성종류적평균발병년령재42세좌우;악성림파류、자궁경암화간암시해지구HIV인군최상견적악성종류;항종류연합항HⅣ치료(ART)능유효개선HIV합병악성종류환자적예후.
Objection To investigate the spectrum and survival status of HIV positive cancer in HuBei province, China. Methods HIV positive cancer patients were added up and followed up who had registered in Zhongnan Hospital between January 2004 and June 2009. The prognostic features were determined for HIV patients with cancer. Results The average age of HIV positive and HIV negative group who suffered with malignant neoplasm were 42.5±8.8 years and 55.1±13.7 years respectively (P ＜0.05), mean CD4 counts were (220.9±142.3)/μl and (554.4±174.3)/μl, respectively (P ＜0.05), the types of common cancer were NHL, cervical cancer, liver cancer and lung cancer, colon cancer, breast cancer, respectively. Anticancer and/or ART treatment were the important positive prognostic factors. Additional factors such as age and CD4 count were associated with survival of cancer patients with HIV infection. Conclusion Mean age of HIV positive cancer patients is about 42 years old. NHL, cervical cancer and liver cancer are HIV associated malignant tumor. ART and anticancer can effectively prolong the survival of HIV infected patients with cancer.