CAJ | 학술논문

目的探讨临床常用的口服降糖药物格列吡嗪及二甲双胍和对Ⅱ型糖尿病人血清胰岛素样生长因子-1,2(IGF-1,2)的影响。方法采用治疗前后自身对照研究，分别给予格列吡嗪或二甲双胍治疗2wk，比较两种药物对Ⅱ型糖尿病患者空腹IGF-1,IGF-2血清水平的影响。结果二甲双胍治疗组(25例)空腹血清IGF-1,IGF-2治疗后无明显变化；格列吡嗪(40例)治疗后空腹血清IGF-1升高[(181.8±104.5)vs(209.0±88.2)ng·ml-1,(P＜0.05)],IGF-2治疗后无明显变化；治疗后2组血糖均明显下降(P均＜O.01)，格列吡嗪组治疗后C肽水平明显升高(P＜0.05)，二甲双胍组治疗后C肽水平无明显变化。结论格列吡嗪和二甲双胍对Ⅱ型糖尿病患者血清IGF-1水平有不同的影响。
목적탐토림상상용적구복강당약물격렬필진급이갑쌍고화대Ⅱ형당뇨병인혈청이도소양생장인자-1,2(IGF-1,2)적영향。방법채용치료전후자신대조연구，분별급여격렬필진혹이갑쌍고치료2wk，비교량충약물대Ⅱ형당뇨병환자공복IGF-1,IGF-2혈청수평적영향。결과이갑쌍고치료조(25례)공복혈청IGF-1,IGF-2치료후무명현변화；격렬필진(40례)치료후공복혈청IGF-1승고[(181.8±104.5)vs(209.0±88.2)ng·ml-1,(P＜0.05)],IGF-2치료후무명현변화；치료후2조혈당균명현하강(P균＜O.01)，격렬필진조치료후C태수평명현승고(P＜0.05)，이갑쌍고조치료후C태수평무명현변화。결론격렬필진화이갑쌍고대Ⅱ형당뇨병환자혈청IGF-1수평유불동적영향。
Aim To study the effects of glipizide and met formin on the serum IGF-1, IGF-2 in patients with type Ⅱ diabetes mellitus; Methods The effect of glipizide(n ＝ 40) and metformin(n ＝ 25) on serum IGF-1, IGF-2 in patients with type Ⅱ diabetes mellitus were compared with self- controlled study. Results In metformin-treated patients , there were not significantly changes in fasting IGF-1 and IGF-2 concentrations, In glipizide-treated patients, there were markedly increased IGF-1 concentrations (181.8+ 104.5) vs (209.0+ 88.2) ng· ml-1(P＜0.05) while serum IGF-2 was not change. There was a significant reduction of blood glucose in two groups at the end of treatment(both P＜0.01), but C-peptide level was markedly increased(P＜0.05) only in glipizide-treated patients. Conclusion The changes of IGF-1 is markedly different between metformin-treated and glipizide-treated patients with type Ⅱ diabetes mellitus.