临床医学
臨床醫學
림상의학
CLINICAL MEDICINE
2009年
1期
112-113
,共2页
骨转移癌%草药%钐%乙二胺甲撑膦酸
骨轉移癌%草藥%釤%乙二胺甲撐膦痠
골전이암%초약%삼%을이알갑탱련산
Bone metastases%Herds%Samarium%EDTMP
目的 利用中草药与153Sm-EDTMP联合治疗骨转移癌,以提高153Sm-EDTMP的疗效和减轻其骨髓抑制的副作用.方法 选择经临床和病理确诊为肿瘤的患者54例,随机分为A、B两组进行研究.A组即153Sm-EDTMP治疗组,30例;B组即153Sm-EDTMP+中草药治疗组,24例.153Sm-EDTMP用量为37～74 MBq/kg,中草药选用祛风通络、除湿解毒、益肾补气填精之类.结果 A组疼痛缓解和生活质量的改善分别为80%和86.1%,外周血白细胞在用药2周后明显下降(P<0.05),血小板在用药后1个月明显下降(P<0.05);B组疼痛缓解和生活质量的改善分别为91.7%和95.8%,外周血象未见明显改变.结论 中草药和153Sm-EDTMP联合治疗骨转移癌具有临床应用价值.
目的 利用中草藥與153Sm-EDTMP聯閤治療骨轉移癌,以提高153Sm-EDTMP的療效和減輕其骨髓抑製的副作用.方法 選擇經臨床和病理確診為腫瘤的患者54例,隨機分為A、B兩組進行研究.A組即153Sm-EDTMP治療組,30例;B組即153Sm-EDTMP+中草藥治療組,24例.153Sm-EDTMP用量為37～74 MBq/kg,中草藥選用祛風通絡、除濕解毒、益腎補氣填精之類.結果 A組疼痛緩解和生活質量的改善分彆為80%和86.1%,外週血白細胞在用藥2週後明顯下降(P<0.05),血小闆在用藥後1箇月明顯下降(P<0.05);B組疼痛緩解和生活質量的改善分彆為91.7%和95.8%,外週血象未見明顯改變.結論 中草藥和153Sm-EDTMP聯閤治療骨轉移癌具有臨床應用價值.
목적 이용중초약여153Sm-EDTMP연합치료골전이암,이제고153Sm-EDTMP적료효화감경기골수억제적부작용.방법 선택경림상화병리학진위종류적환자54례,수궤분위A、B량조진행연구.A조즉153Sm-EDTMP치료조,30례;B조즉153Sm-EDTMP+중초약치료조,24례.153Sm-EDTMP용량위37～74 MBq/kg,중초약선용거풍통락、제습해독、익신보기전정지류.결과 A조동통완해화생활질량적개선분별위80%화86.1%,외주혈백세포재용약2주후명현하강(P<0.05),혈소판재용약후1개월명현하강(P<0.05);B조동통완해화생활질량적개선분별위91.7%화95.8%,외주혈상미견명현개변.결론 중초약화153Sm-EDTMP연합치료골전이암구유림상응용개치.
Objective To improve anti-pain efficiency of 153Sm-EDTMP and reduce its adverse side-effect of marrow suppression,herbs were used to treat metastatic carcinoma of bone with 153Sm-EDTMP. Methods The patients were classified into two groups,group A:30 patients were treated only with 153Sm-EDTMP;group B:24 patients were treated with 153Sm-EDTMP and herds.The administered amount of 153Sm-EDTMP was 37-74 MBq/kg in groups of patients.The herbs include drugs for expelling wind,promoting blood circulation and restoring flow,removing dampness and detoxicating,tonifying the kidney,replenishing Qi,promoting essence and producing marrow.Results In group A:the anti-pain effective rate and living improvement rate were respectively 80% and 86.7%,the white bleed cell count was below baseline value 2 weeks post-treatment(P<0.05) and the platelet count was below baseline 4 weeks post-treatmen(P<0.05).Ingroup B:the anti-pain effective rate and living improvement rate were respectively 91.7% and 95.8%,the levels of blood cell counts were not significantly different from the baseline data before treatment (P>0.05).Conclusion 153Sm-EDTMP in conjunction with herbs being used to treat metastatic carcinoma of bone could be valuable in improving anti-pain efficiency of 153Sm-EDTMP and reducing it's adverse side-effect of marrow suppression.
