CAJ | 학술논문

采用乳化-溶剂蒸发法制备载盐酸米托蒽醌的聚乳酸-聚赖氨酸-精氨酰-甘氨酰-门冬氨酸纳米粒,以粒径和包封率为评价指标,用正交设计优化制备工艺.结果表明,照优化方案制备的纳米粒呈大小均匀的圆球形,平均粒径(186±2.37)nm,平均包封率(94.7±1.46)%,在pH 7.4磷酸盐缓冲液中192h累积释放量为61%.
채용유화-용제증발법제비재염산미탁은곤적취유산-취뢰안산-정안선-감안선-문동안산납미립,이립경화포봉솔위평개지표,용정교설계우화제비공예.결과표명,조우화방안제비적납미립정대소균균적원구형,평균립경(186±2.37)nm,평균포봉솔(94.7±1.46)%,재pH 7.4린산염완충액중192h루적석방량위61%.
Mitoxantrone-loaded PLA-PLL-RGD [poly (lactic acid-co-L-lysine) modified by RGD peptide] nanoparticles were prepared by emulsion-solvent evaporation method. The preparation was optimized by orthogonal design with the diameter and encapsulation efficiency as the evaluation indexes. The products were spherical with the average diameter of (186±2.37)nm and encapsulation efficiency of (94.7±1.46)%. The in vitro release in pH 7.4 phosphate buffer solution at 192 h was 61%.