CAJ | 학술논문

目的探索急性再生障碍性贫血(AA)的免疫学发病机制及抗胸腺细胞球蛋白(ATG)的免疫调节机制.方法利用流式细胞仪测定74例急性AA患者与55例正常人的T淋巴细胞亚群及其中30例接受ATG治疗前后T淋巴细胞亚群的变化.结果与对照组相比.急性AA组的总T淋巴细胞、总B淋巴细胞、CD4+T淋巴细胞百分比均较正常组高,而CD56+、CD3+DR+百分比均较正常组低.ATG治疗有效患者(24例)治疗后CD8+、CD56+、CD3+DR+百分比增加,CD4+、CD4+/CD8+百分比下降.结论与慢性AA的发病机制不同.急性AA CD4+T淋巴细胞百分比异常升高.推断CD4+T淋巴细胞可能主要分化为Th1细胞.起抑制造血作用.
목적 탐색급성재생장애성빈혈(AA)적면역학발병궤제급항흉선세포구단백(ATG)적면역조절궤제.방법 이용류식세포의측정74례급성AA환자여55례정상인적T림파세포아군급기중30례접수ATG치료전후T림파세포아군적변화.결과 여대조조상비.급성AA조적총T림파세포、총B림파세포、CD4+T림파세포백분비균교정상조고,이CD56+、CD3+DR+백분비균교정상조저.ATG치료유효환자(24례)치료후CD8+、CD56+、CD3+DR+백분비증가,CD4+、CD4+/CD8+백분비하강.결론 여만성AA적발병궤제불동.급성AA CD4+T림파세포백분비이상승고.추단CD4+T림파세포가능주요분화위Th1세포.기억제조혈작용.
Objective To explore the immunopathogenesis of acute AA and the effect of ATG in immunological regulation. Method T cell subsets of 74 acute AA patients,55 health adults and 30 acute AA patients were measured with flow eytometry after ATG therapy. Result Compared with the control, the percentage of total T, total B and CD4+ T cell count in acute AA were higher, while the percentage of CD56+,CD3+DR+ count were lower. In the 24 patients who improved after ATG therapy, the percentage of CD4+ and CD4+/CD8+ decreased, while the percentage of CDS+, CD56+ and CD3+DR + raised. Conclusion Acute AA may have a different immunity mechanism from chronic AA. CD4+T lymphocytes may be a critical factor in the pathophysiology, which would be polarized toward a Thl pattern of cytokine production to suppress haematogenesis.