中华流行病学杂志
中華流行病學雜誌
중화류행병학잡지
CHINESE JOURNAL OF EPIDEMIOLOGY
2009年
11期
1135-1138
,共4页
王霞%丁心平%苏斌%徐臣%刘媛%张言敏%祝军玲%韩丽涛%阮玉华%邵一鸣
王霞%丁心平%囌斌%徐臣%劉媛%張言敏%祝軍玲%韓麗濤%阮玉華%邵一鳴
왕하%정심평%소빈%서신%류원%장언민%축군령%한려도%원옥화%소일명
艾滋病病毒感染%既往献血员%中位生存时间%抗病毒治疗
艾滋病病毒感染%既往獻血員%中位生存時間%抗病毒治療
애자병병독감염%기왕헌혈원%중위생존시간%항병독치료
Human immunodeficiency virus infection%Former blood donors%Median survival time%Antiretroviral therapy
目的 了解安徽省阜阳市因献血感染HIV既往献血员的生存时间及抗病毒治疗效果.方法 对HIV阳性既往献血员进行回顾性调查.同时统计存活的HIV感染者参与抗病毒治疗情况.利用韦伯(Weibull)函数计算中位生存时间,通过比较抗病毒治疗后的实际死亡例数和未治疗感染者的理论死亡例数来评价抗病毒治疗效果.结果 安徽省阜阳市既往献血人群HIV感染平均时间为1994年底,未接受抗病毒治疗的HIV阳性既往献血人群中位生存时间为10.8年.截至2008年9月,感染HIV的159例既往献血员中有74例接受抗病毒治疗,调查时的CD4+T淋巴细胞计数均数为475.1个/μl,显著高于治疗前的247.8个/μl(P<0.0001).实际死亡761例,比利用韦伯函数计算的预期死亡数减少31.7%.结论 研究结果与UNAIDS提出的未使用抗病毒药物治疗HIV感染的中位生存时间为11年左右基本相符.自2003年以来,艾滋病抗病毒治疗减少了约1/3的预期死亡例数.
目的 瞭解安徽省阜暘市因獻血感染HIV既往獻血員的生存時間及抗病毒治療效果.方法 對HIV暘性既往獻血員進行迴顧性調查.同時統計存活的HIV感染者參與抗病毒治療情況.利用韋伯(Weibull)函數計算中位生存時間,通過比較抗病毒治療後的實際死亡例數和未治療感染者的理論死亡例數來評價抗病毒治療效果.結果 安徽省阜暘市既往獻血人群HIV感染平均時間為1994年底,未接受抗病毒治療的HIV暘性既往獻血人群中位生存時間為10.8年.截至2008年9月,感染HIV的159例既往獻血員中有74例接受抗病毒治療,調查時的CD4+T淋巴細胞計數均數為475.1箇/μl,顯著高于治療前的247.8箇/μl(P<0.0001).實際死亡761例,比利用韋伯函數計算的預期死亡數減少31.7%.結論 研究結果與UNAIDS提齣的未使用抗病毒藥物治療HIV感染的中位生存時間為11年左右基本相符.自2003年以來,艾滋病抗病毒治療減少瞭約1/3的預期死亡例數.
목적 료해안휘성부양시인헌혈감염HIV기왕헌혈원적생존시간급항병독치료효과.방법 대HIV양성기왕헌혈원진행회고성조사.동시통계존활적HIV감염자삼여항병독치료정황.이용위백(Weibull)함수계산중위생존시간,통과비교항병독치료후적실제사망례수화미치료감염자적이론사망례수래평개항병독치료효과.결과 안휘성부양시기왕헌혈인군HIV감염평균시간위1994년저,미접수항병독치료적HIV양성기왕헌혈인군중위생존시간위10.8년.절지2008년9월,감염HIV적159례기왕헌혈원중유74례접수항병독치료,조사시적CD4+T림파세포계수균수위475.1개/μl,현저고우치료전적247.8개/μl(P<0.0001).실제사망761례,비이용위백함수계산적예기사망수감소31.7%.결론 연구결과여UNAIDS제출적미사용항병독약물치료HIV감염적중위생존시간위11년좌우기본상부.자2003년이래,애자병항병독치료감소료약1/3적예기사망례수.
Objective To estimate the median survival and the effect of antiretroviral therapy (ART) among HIV-positive former blood donors of Fuyang in Anhui province, China. Methods A retrospective survey was conducted among HIV-positive former blood donors, and data was collected on survivors who had received ART. Weibull function was used to calculate median survival of HIV-positive former blood donors. The effect of ART was estimated through comparing the actual number of deaths after ART with the expected number of deaths in those who did not receive ART. Results The median period of HIV infection was at the end of 1994, with the median survival of HIV-positive former blood donors in Fuyang as 10.8 years. By the end of September 2008, among 159 former blood donors, 74 received ART, with their mean CD4+ T-cell count increased from 247.8/μl to 475.1/μl (P<0.0001). 76 of the 159 former blood donors died. When comparing the expected number of deaths calculated by Weibull function, 31.7% of the total number of deaths was reduced. Conclusion Result from this study was in consistent to the UNAIDS' figures that in the absence of treatment, the net median survival time after infection with HIV was estimated to be 11 years and ART has reduced about one third of the expected deaths.
