CAJ | 학술논문

目的比较度洛西汀与帕罗西汀治疗抑郁伴焦虑障碍的疗效和安全性.方法对24例符合CCMD-3抑郁发作和广泛性焦虑诊断标准的患者随机双盲进入度洛西汀或帕罗西汀组治疗6周,分别在治疗前及第1、2、4、6周末进行汉密尔顿抑郁量表17项(HAMD)、汉密尔顿焦虑量表(HAMA)和临床疗效总评量表的病情严重程度(CGI-SI)评定,进行体格检查、实验室检查,及采用副反应量表(TESS)评估用药安全性.结果经6周治疗后显示,度洛西汀总体疗效比帕罗西汀稍好且起效快,效果良好,在治疗第1周末HAMD总分与帕罗西汀组有显著性差异(P＜0.05).两组不良反应均较轻微.结论度洛西汀抗抑郁及抗焦虑作用确切,可用于治疗抑郁症伴焦虑障碍.
목적 비교도락서정여파라서정치료억욱반초필장애적료효화안전성.방법 대24례부합CCMD-3억욱발작화엄범성초필진단표준적환자수궤쌍맹진입도락서정혹파라서정조치료6주,분별재치료전급제1、2、4、6주말진행한밀이돈억욱량표17항(HAMD)、한밀이돈초필량표(HAMA)화림상료효총평량표적병정엄중정도(CGI-SI)평정,진행체격검사、실험실검사,급채용부반응량표(TESS)평고용약안전성.결과 경6주치료후현시,도락서정총체료효비파라서정초호차기효쾌,효과량호,재치료제1주말HAMD총분여파라서정조유현저성차이(P＜0.05).량조불량반응균교경미.결론 도락서정항억욱급항초필작용학절,가용우치료억욱증반초필장애.
Objective To control the efficacy of duloxetine and paroxetine in treatment of co-occurring depression and anxiety disorder.Methods 24 patients with a diagnosis of major depressive episode and anxiety disorder(CCMD-3)were randomly assigned to 6 weeks of treatment with duloxetine or paroxetine in double-blind.The efficacy was assessed with HAMD-17、HAMA and CGI-SI at the end of baseline and 1,2,4,6 weeks after treatment.Safety was estimated by TESS,laboratory and physical examination.Results After 6 weeks treatment,the result based on the reduction rate of HAMD and HAMA showed duloxetine was comparably effective as paroxetine.The HAMD scores decreased significantly at the end of 1 week after treatment between two groups(p<0.05).The adverse effects were mild.Conclusions Duloxetine has positive effectiveness in co-occurring depression and anxiety disorder.