中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2010年
1期
19-21
,共3页
阿司匹林%血栓素B_2%6-酮-前列腺素%超早期脑梗死
阿司匹林%血栓素B_2%6-酮-前列腺素%超早期腦梗死
아사필림%혈전소B_2%6-동-전렬선소%초조기뇌경사
Aspirin%Thromboxane B_2%6-ketone -prostaglandin%Hyper-acute cerebral infarction
目的 探讨不同阿司匹林抵抗类型的超早期脑梗死患者服用阿司匹林后血栓索B_2(TXB_2)与6-酮-前列腺素(6-k-PG)F1 α水平的变化及临床意义.方法 将63例超早期脑梗死患者根据阿司匹林抵抗类型分为阿司匹林抵抗(AR)组、阿司匹林半抵抗(ASR)组和阿司匹林敏感(AS)组,分别测定三组患者服用阿司匹林(100 mg/d)前及2周后TXB_2及6-k-PGF1α水平及两者比值,并进行对比分析及预后评估.结果 AS组总有效率[87.0%(20/23)]显著高于ASR组[55.0%(11/20)]和AR组[30.0%(6/20)],差异有统计学意义(P<0.05);AS组TXB_2和6-k-PGF1α比值增高的患者比例较低.用药前三组患者TXB_2、6-k-PGF1α水平比较差异无统计学意义.用药2周后,三组患者TXB2水平较用药前均显著下降,6-k-PGF1α水平较用药前均显著上升(P<0.01),而且AR组下降或上升幅度小于AS组和ASR组(P<0.01).结论 阿司匹林可降低超早期脑梗死患者的TXB_2水平,并提高6-k-PGF1α水平,有可能在一定程度上降低其再次血栓形成的危险,同时监测TXB_2和6-k-PGF1α比值有助于评估预后.
目的 探討不同阿司匹林牴抗類型的超早期腦梗死患者服用阿司匹林後血栓索B_2(TXB_2)與6-酮-前列腺素(6-k-PG)F1 α水平的變化及臨床意義.方法 將63例超早期腦梗死患者根據阿司匹林牴抗類型分為阿司匹林牴抗(AR)組、阿司匹林半牴抗(ASR)組和阿司匹林敏感(AS)組,分彆測定三組患者服用阿司匹林(100 mg/d)前及2週後TXB_2及6-k-PGF1α水平及兩者比值,併進行對比分析及預後評估.結果 AS組總有效率[87.0%(20/23)]顯著高于ASR組[55.0%(11/20)]和AR組[30.0%(6/20)],差異有統計學意義(P<0.05);AS組TXB_2和6-k-PGF1α比值增高的患者比例較低.用藥前三組患者TXB_2、6-k-PGF1α水平比較差異無統計學意義.用藥2週後,三組患者TXB2水平較用藥前均顯著下降,6-k-PGF1α水平較用藥前均顯著上升(P<0.01),而且AR組下降或上升幅度小于AS組和ASR組(P<0.01).結論 阿司匹林可降低超早期腦梗死患者的TXB_2水平,併提高6-k-PGF1α水平,有可能在一定程度上降低其再次血栓形成的危險,同時鑑測TXB_2和6-k-PGF1α比值有助于評估預後.
목적 탐토불동아사필림저항류형적초조기뇌경사환자복용아사필림후혈전색B_2(TXB_2)여6-동-전렬선소(6-k-PG)F1 α수평적변화급림상의의.방법 장63례초조기뇌경사환자근거아사필림저항류형분위아사필림저항(AR)조、아사필림반저항(ASR)조화아사필림민감(AS)조,분별측정삼조환자복용아사필림(100 mg/d)전급2주후TXB_2급6-k-PGF1α수평급량자비치,병진행대비분석급예후평고.결과 AS조총유효솔[87.0%(20/23)]현저고우ASR조[55.0%(11/20)]화AR조[30.0%(6/20)],차이유통계학의의(P<0.05);AS조TXB_2화6-k-PGF1α비치증고적환자비례교저.용약전삼조환자TXB_2、6-k-PGF1α수평비교차이무통계학의의.용약2주후,삼조환자TXB2수평교용약전균현저하강,6-k-PGF1α수평교용약전균현저상승(P<0.01),이차AR조하강혹상승폭도소우AS조화ASR조(P<0.01).결론 아사필림가강저초조기뇌경사환자적TXB_2수평,병제고6-k-PGF1α수평,유가능재일정정도상강저기재차혈전형성적위험,동시감측TXB_2화6-k-PGF1α비치유조우평고예후.
Objective To study the effects and significance of thrombexane -B_2(TXB_2)and six-ketone-prostaglandin(6-k-PG)F1 α levels in the primary type of hyper-acute cerebral infarction with different sensitivities to aspirin.Methods Sixty-three patients with primary type of hyper-acute cerebral infarction were divided into three groups based on their sensitivities to aspirin:aspirin resistance(AR)group,aspirin semiresistance(ASR)group,aspirin sensitivity(AS)group.TXB_2 and 6-k-PGF1α levels were measured,compared and analyzed in the three groups before and two weeks after taking aspirin(100 mg/d).Results The total effective rate in AS group[87.0%(20/23)]was significantly higher than that in ASR group[55.0%(11/20)]and AR group[30.0%(6/20)](P<0.05).There was no significant difference of TXB_2 and 6-k-PGF1 α among the three groups before taking aspirin.After taking aspirin for two weeks,TXB_2 leveh in all the three groups were lower than those before making aspirin(P<0.01),6-k-PGF1α levels in all the three groups were higher than those before taking aspirin(P<0.01).Conclusions Aspirin can decrease the TXB_2 concentration and increase the 6-k-PGF1α concentration of the primary hyper-acute cerebral infarction. It may be reduce the risks of re-infarction after the primary acute infarction. Monitoring the concentration of TXB_2 and 6-k-PGF1α can be helpful to evaluate rehabilitation prognosis.
