中国医药
中國醫藥
중국의약
CHINA MEDICINE
2012年
10期
1236-1238
,共3页
鞠海兵%徐昕明%舒子正%王光琳%李丽风%宋洁%孙晓娟%于菁
鞠海兵%徐昕明%舒子正%王光琳%李麗風%宋潔%孫曉娟%于菁
국해병%서흔명%서자정%왕광림%리려풍%송길%손효연%우정
糖尿病,2型%叶酸%8-异前列腺素F2α%6-酮前列腺素F1α%氧化应激
糖尿病,2型%葉痠%8-異前列腺素F2α%6-酮前列腺素F1α%氧化應激
당뇨병,2형%협산%8-이전렬선소F2α%6-동전렬선소F1α%양화응격
Diabetes,type 2%Folate%8-isoprostane F2α%6-keto-prostaglandin F1α%Oxidative stress
目的 观察叶酸对2型糖尿病患者血清8-异前列腺素F2α(8-IPF2α)和6-酮前列腺素F1α(6-K-PGF1α)的影响,探讨叶酸对2型糖尿病患者氧化应激的影响.方法 98例口服降糖药治疗的2型糖尿病患者随机分为2组,完成试验88例,试验组42例,对照组46例.对照组继续给予降糖治疗；试验组在原降糖治疗的基础上,加用叶酸5 mg口服,3次/d.治疗前和治疗3个月后测定2组患者血清同型半胱氨酸(Hcy)、叶酸、8-IPF2α、6-K-PGF1α水平.结果 治疗3个月后,试验组患者血清叶酸、6-K-PGF1α高于对照组[(13.3±2.6)pmol/L比(11.5±2.4)pmol/L,(84±14)ng/L比(70±12)ng/L,P＜0.05],血清Hcy、8-IPF2α低于对照组[(9.2 ±2.3)μmol/L比(11.1±2.8)μmol/L、(21±3)ng/L比(35±7)ng/L,P＜0.05或P＜0.01].结论 叶酸对2型糖尿病患者有抗氧化应激的作用.
目的 觀察葉痠對2型糖尿病患者血清8-異前列腺素F2α(8-IPF2α)和6-酮前列腺素F1α(6-K-PGF1α)的影響,探討葉痠對2型糖尿病患者氧化應激的影響.方法 98例口服降糖藥治療的2型糖尿病患者隨機分為2組,完成試驗88例,試驗組42例,對照組46例.對照組繼續給予降糖治療；試驗組在原降糖治療的基礎上,加用葉痠5 mg口服,3次/d.治療前和治療3箇月後測定2組患者血清同型半胱氨痠(Hcy)、葉痠、8-IPF2α、6-K-PGF1α水平.結果 治療3箇月後,試驗組患者血清葉痠、6-K-PGF1α高于對照組[(13.3±2.6)pmol/L比(11.5±2.4)pmol/L,(84±14)ng/L比(70±12)ng/L,P＜0.05],血清Hcy、8-IPF2α低于對照組[(9.2 ±2.3)μmol/L比(11.1±2.8)μmol/L、(21±3)ng/L比(35±7)ng/L,P＜0.05或P＜0.01].結論 葉痠對2型糖尿病患者有抗氧化應激的作用.
목적 관찰협산대2형당뇨병환자혈청8-이전렬선소F2α(8-IPF2α)화6-동전렬선소F1α(6-K-PGF1α)적영향,탐토협산대2형당뇨병환자양화응격적영향.방법 98례구복강당약치료적2형당뇨병환자수궤분위2조,완성시험88례,시험조42례,대조조46례.대조조계속급여강당치료；시험조재원강당치료적기출상,가용협산5 mg구복,3차/d.치료전화치료3개월후측정2조환자혈청동형반광안산(Hcy)、협산、8-IPF2α、6-K-PGF1α수평.결과 치료3개월후,시험조환자혈청협산、6-K-PGF1α고우대조조[(13.3±2.6)pmol/L비(11.5±2.4)pmol/L,(84±14)ng/L비(70±12)ng/L,P＜0.05],혈청Hcy、8-IPF2α저우대조조[(9.2 ±2.3)μmol/L비(11.1±2.8)μmol/L、(21±3)ng/L비(35±7)ng/L,P＜0.05혹P＜0.01].결론 협산대2형당뇨병환자유항양화응격적작용.
Objective To explore the effects of folate on changes of 8-isoprostane F2α(8-IPF2α),6-keto-prostaglandin-F1α(6-K-PGF1α)and oxidative stress in patients with type 2 diabetes mellitus.Methods Ninetyeight patients with type 2 diabetes mellitus on oral hypoglycemic drugs were randomly divided into two groups ; 88 of 98 subjects completed the study.There were 46 participants(control group)who received a 3-month course of oral hypoglycemic drugs;the remaining 42 patients(experiment group)received oral hypoglycemic drugs and folate 15 mg daily.Serum Hcy,folate,8-IPF2α,6-K-PGF1α were measured at baseline and after treatment.Results There was no significant difference in clinical data and serum Hcy,folate,8-IPF2α,6-K-PGF1α between two groups before treatment.Compared with the control group,experiment group with folate showed a significant increase in serum folate [(13.3 ±2.6)pmol/L vs(11.5 ± 2.4)pmol/L,P ＜0.05]and 6-K-PGF1α [(84 ± 14)ng/L vs(70 ± 12) ng/L,P ＜ 0.05]and decreased in serum Hcy [(19.2 ± 2.3)μmol/L vs(11.1 ± 2.8)μmol/L,P ＜ 0.05]and 8-IPF2α[(21 ± 3)ng/L vs(35 ± 7)ng/L,P ＜ 0.01].Conclusion The administration of folate reduces oxidative stress in type 2 diabetes mellitus.
