CAJ | 학술논문

目的探讨原发性高血压患者血压的季节性变化及其与各气象因素的关系.方法用整群抽样法抽取青州市3个乡镇的原发性高血压患者1800例,男1155例,女645例,年龄29～85岁,平均年龄61.3岁.2008年7月至2009年6月测量患者8:00～11:00时坐位肱动脉血压,每隔7～14天测量一次,共12个月.将血压值与测量时当地的气温、室温、湿度、平均气压等气象数据配对后进行多元回归分析.结果观察组的血压上半年成下降趋势,其拐点在4月份,夏季最低.下半年以9～10月份为拐点逐渐升高,冬季达高峰.除春秋季之间外,各季节间的收缩压、舒张压比较,差异均有统计学意义(P＜0.05或＜0.01).收缩压、舒张压均与气温(beta=-0.08,t=-2.39,P＜0.05;beta=-0.24,t=-6.21,P＜0.01)、室温(beta=-0.08,t=-2.39,P＜0.05;beta=-0.24,t=-6.21,P＜0.01)成直线负相关.结论原发性高血压患者的血压存在季节性改变,血压在春、秋季出现春降秋升的明显波动,这种改变以收缩压较明显,与室温关系更密切.
목적 탐토원발성고혈압환자혈압적계절성변화급기여각기상인소적관계.방법 용정군추양법추취청주시3개향진적원발성고혈압환자1800례,남1155례,녀645례,년령29～85세,평균년령61.3세.2008년7월지2009년6월측량환자8:00～11:00시좌위굉동맥혈압,매격7～14천측량일차,공12개월.장혈압치여측량시당지적기온、실온、습도、평균기압등기상수거배대후진행다원회귀분석.결과 관찰조적혈압상반년성하강추세,기괴점재4월빈,하계최저.하반년이9～10월빈위괴점축점승고,동계체고봉.제춘추계지간외,각계절간적수축압、서장압비교,차이균유통계학의의(P＜0.05혹＜0.01).수축압、서장압균여기온(beta=-0.08,t=-2.39,P＜0.05;beta=-0.24,t=-6.21,P＜0.01)、실온(beta=-0.08,t=-2.39,P＜0.05;beta=-0.24,t=-6.21,P＜0.01)성직선부상관.결론원발성고혈압환자적혈압존재계절성개변,혈압재춘、추계출현춘강추승적명현파동,저충개변이수축압교명현,여실온관계경밀절.
Objective To study seasonal variation of blood pressure (BP) in patients with essential hypertension (EH) and its association with meteorological elements. Methods In total, 1800 patients with essential hypertension were recruited by cluster sampling from three townships and towns in Qingzhou,Shandong province, 1155 men and 645 women, with an average age of 61.3 years (ranging from 29 to 85years). BP was measured for all of them in sitting position at 8:00 in the morning every seven to 14 days during July 2008 to June 2009. Local meteorological data were collected accordingly such as temperature,humidity and atmospheric pressure, and multivariate regression analysis was performed to show their association. Results In general, BP in patients with EH presented a decreasing trend during the first half year of observation, with the lowest in the summer ( May to August). From September to October, their BP began to increase gradually, and reached the peak in the winter ( November to February nest year). There was significant difference in systolic BP (SBP) and diastolic BP (DBP) between various seasons (Pspring-summer = 0.002 and 0.000, Pwinter-spring = 0.001 and 0.000, Psummer-autumn = 0.045 and 0.000,Psummer-winter =0. 000 and 0. 000, Pautumn-winter =0. 000 and 0. 000, respectively), except for those between the spring and autumn. Both SBP and DBP reversely associated with outdoor air temperature and room temperature(beta= -0.08, t = -2.39, P ＜0.05 and beta = -0.24, t = -6.21, P ＜0.01,respectively), (beta = -0.08, t = -2.39, P ＜0.05 and beta = -0.24, t = -6.21, P ＜0.01,respectively). Conclusions BP in patients with EH reveals seasonal variation, with the lowest in the summer and the highest in the winter and evident fluctuation in the spring and autumn, especially in SBP,which associates with room temperature and their blood vessel elasticity.