中华神经医学杂志
中華神經醫學雜誌
중화신경의학잡지
CHINESE JOURNAL OF NEUROMEDICINE
2012年
6期
622-625
,共4页
于志虎%肖华%赵振林%胡栋%张清华%毕中胜
于誌虎%肖華%趙振林%鬍棟%張清華%畢中勝
우지호%초화%조진림%호동%장청화%필중성
安脑活血胶囊%高血压脑出血%血液流变学指标%神经功能缺失评分%格拉斯哥昏迷评分
安腦活血膠囊%高血壓腦齣血%血液流變學指標%神經功能缺失評分%格拉斯哥昏迷評分
안뇌활혈효낭%고혈압뇌출혈%혈액류변학지표%신경공능결실평분%격랍사가혼미평분
Annaohuoxue capsule%Hypertensive cerebral hemorrhage%Hemorrheology index%Neurological impairment scale%Glasgow coma scale
目的 观察活血化瘀方药安脑活血胶囊对高血压脑出血患者的疗效和安全性. 方法 选择南方医科大学附属花都医院神经外科自2010年6月至2011年11月收治的脑出血患者93例,其中安脑活血胶囊组31例、天丹通络胶囊组32例、安慰剂组30例,分别于发病后7d开始服用相应药物,疗程21d,其他基础治疗相同.疗程结束后第一天记录并比较3组患者血液流变学指标、神经功能缺损评分、GCS评分的差异. 结果 治疗后安脑活血胶囊组患者血浆粘度、RBC聚集指数低于天丹通络胶囊组,差异有统计学意义(P＜0.05)；3组患者临床疗效的差异有统计学意义(P＜0.05),其中安脑活血胶囊组治疗效果最佳,天丹通络胶囊组患者次之,安慰剂组最差;安脑活血胶囊组GCS评分高于天丹通络胶囊组及安慰剂组,差异有统计学意义(P＜0.05). 结论 活血化瘀方药安脑活血胶囊对血液流变学各项指标、神经功能缺失预后评分及格拉斯哥昏迷评分有不同程度的改善作用,且其疗效优于安慰剂.
目的 觀察活血化瘀方藥安腦活血膠囊對高血壓腦齣血患者的療效和安全性. 方法 選擇南方醫科大學附屬花都醫院神經外科自2010年6月至2011年11月收治的腦齣血患者93例,其中安腦活血膠囊組31例、天丹通絡膠囊組32例、安慰劑組30例,分彆于髮病後7d開始服用相應藥物,療程21d,其他基礎治療相同.療程結束後第一天記錄併比較3組患者血液流變學指標、神經功能缺損評分、GCS評分的差異. 結果 治療後安腦活血膠囊組患者血漿粘度、RBC聚集指數低于天丹通絡膠囊組,差異有統計學意義(P＜0.05)；3組患者臨床療效的差異有統計學意義(P＜0.05),其中安腦活血膠囊組治療效果最佳,天丹通絡膠囊組患者次之,安慰劑組最差;安腦活血膠囊組GCS評分高于天丹通絡膠囊組及安慰劑組,差異有統計學意義(P＜0.05). 結論 活血化瘀方藥安腦活血膠囊對血液流變學各項指標、神經功能缺失預後評分及格拉斯哥昏迷評分有不同程度的改善作用,且其療效優于安慰劑.
목적 관찰활혈화어방약안뇌활혈효낭대고혈압뇌출혈환자적료효화안전성. 방법 선택남방의과대학부속화도의원신경외과자2010년6월지2011년11월수치적뇌출혈환자93례,기중안뇌활혈효낭조31례、천단통락효낭조32례、안위제조30례,분별우발병후7d개시복용상응약물,료정21d,기타기출치료상동.료정결속후제일천기록병비교3조환자혈액류변학지표、신경공능결손평분、GCS평분적차이. 결과 치료후안뇌활혈효낭조환자혈장점도、RBC취집지수저우천단통락효낭조,차이유통계학의의(P＜0.05)；3조환자림상료효적차이유통계학의의(P＜0.05),기중안뇌활혈효낭조치료효과최가,천단통락효낭조환자차지,안위제조최차;안뇌활혈효낭조GCS평분고우천단통락효낭조급안위제조,차이유통계학의의(P＜0.05). 결론 활혈화어방약안뇌활혈효낭대혈액류변학각항지표、신경공능결실예후평분급격랍사가혼미평분유불동정도적개선작용,차기료효우우안위제.
Objective To observe the clinical curative effect of Annaohuoxue capsules, a prescription of promoting blood circulation and removing blood stasis, on patients with hypertensive cerebral hemorrhage and explore its safety. Methods Ninety-three patients with hypertensive cerebral hemorrhage,admitted to our hospital from June 2010 to November 201 i,were chosen and randomly divided into Arnaohuoxue capsule treatment group (group A,n=31),Tiandantongluo capsule treatment group (group B,n=32) and placebo control group (group C,n=30); After 7 d of onset,treatments were given,respectively,for 21 d.Hemorrheology,scores of neurological impairment,Glasgow coma scale (GCS) scores were recorded and compared in these groups before and after treatment. Results The plasma viscosity,and aggregation index of R BCs in patients from group A were significantly lower than those in patients from group B (P＜0.05); statistically significant difference on the clinical efficacy was noted between each 2 groups (P＜0.05):the outcome of group A was the best,that of group B was better,and that of group C was the worst.The GCS scores in patients from group A were significantly higher than those in patients from group B and group C (P＜0.05) Conclusion Annaohuoxue capsules can improve the hemorrheology indices and neurological impairment,and decrease the GCS scores in varying degrees,and the treatment efficiency of Annaohuoxue capsules is much better than placebo.
