CAJ | 학술논문

目的观察特发件脉络膜新生血管(CNV)患者血清相关因子水平的改变.方法回顾分析临床确诊为特发性CNV的21例患者21只眼(CNV组)的临床资料.选取20名正常志愿者20只眼作为正常对照组.分别抽取两组受试者静脉血,采用酶联免疫吸附剂测定法和免疫散射比浊法测定血清的血管内皮生长因子(VEGF),肿瘤坏死因子α(TNFα),白介素1-β(IL1-β),免疫球蛋白IgG、IgA、IgM、IgE,总补体CH_(50)、补体C_3、C_4,C反应蛋白(CRP)的浓度.结果 CNV组血清VEGF浓度显著高于正常对照组(t=2.340,P=0.025),IgE浓度显著低于正常对照组(Z=-2.765,P=0.006);其余血清因子浓度与正常对照组相比,差异均无统计学意义(P>0.05).结论 VEGF和IgE可能参与了特发性CNV的形成.
목적 관찰특발건맥락막신생혈관(CNV)환자혈청상관인자수평적개변.방법 회고분석림상학진위특발성CNV적21례환자21지안(CNV조)적림상자료.선취20명정상지원자20지안작위정상대조조.분별추취량조수시자정맥혈,채용매련면역흡부제측정법화면역산사비탁법측정혈청적혈관내피생장인자(VEGF),종류배사인자α(TNFα),백개소1-β(IL1-β),면역구단백IgG、IgA、IgM、IgE,총보체CH_(50)、보체C_3、C_4,C반응단백(CRP)적농도.결과 CNV조혈청VEGF농도현저고우정상대조조(t=2.340,P=0.025),IgE농도현저저우정상대조조(Z=-2.765,P=0.006);기여혈청인자농도여정상대조조상비,차이균무통계학의의(P>0.05).결론 VEGF화IgE가능삼여료특발성CNV적형성.
Objective To observe the change of serum-associated factors concentrations in the patients with idiopathic choroidal neovascularization (CNV).Methods The clinical data of 21 patients (21 eyes) with idiopathic CNV (CNV group) and 20 normal individuals (control group) were retrospective analyzed.Serous concentrations of vascular endothelial growth factor (VEGF),tumor necrosis factor α(TNFα),interleukin 1-β(IL1-β),IgG,IgA,IgM,IgE,CH_(50),C_3,C_4 and C-reactive protein (CRP) were assayed by enzyme-linked immunosorbent assay (ELISA) and immunonephelometry.Results The level of VEGF in CNV group was significantly higher than that in control group (t=2.340,P=0.025).The level of IgE in CNV group was significantly lower than that in control group(Z=-2.765,P=0.006).The other factors were not significantly different between the two groups(P>0.05).Conclusion VEGF and IgE may play an important role in the formation of idiopathic CNV.