CAJ | 학술논문

目的分析接受三维适形放疗( 3DCRT)脑干胶质瘤患者的生存时间及影响生存时间的相关因素.方法 2004年10月至2008年12月36例明确诊断为脑干胶质瘤的患者,均给予局部病灶3DCRT,剂量50-54 Gy,25 ～ 30次,5～6周.放疗期间观察并记录患者症状、体征及放疗不良反应,评价疗效,随访至诊断后3年,采用Kaplan-Meire法进行生存分析.结果儿童组(23例)中位生存时间9个月,成年人组(13例)中位生存时间15个月.儿童组及成年人组1、2、3年生存率分别为43.5％(10/23)与76.9％(10/13)、26.1％(6/23)与46.2％(6/13)、8.7％(2/23)与38.5 ％(5/13).入院时Kamofsky评分(x2=20.059,P=0.000)、病变累及桥脑与否(x2=17.585,P=0.000)、影像学分型(x2=21.247,P=0.000)是影响患者生存的因素.结论 3DCRT是脑干胶质瘤有效的治疗方法,儿童发病、病变侵袭桥脑、弥散型以及Karnofsky评分＜80分是预后不良的危险因素.
목적 분석접수삼유괄형방료( 3DCRT)뇌간효질류환자적생존시간급영향생존시간적상관인소.방법 2004년10월지2008년12월36례명학진단위뇌간효질류적환자,균급여국부병조3DCRT,제량50-54 Gy,25 ～ 30차,5～6주.방료기간관찰병기록환자증상、체정급방료불량반응,평개료효,수방지진단후3년,채용Kaplan-Meire법진행생존분석.결과 인동조(23례)중위생존시간9개월,성년인조(13례)중위생존시간15개월.인동조급성년인조1、2、3년생존솔분별위43.5％(10/23)여76.9％(10/13)、26.1％(6/23)여46.2％(6/13)、8.7％(2/23)여38.5 ％(5/13).입원시Kamofsky평분(x2=20.059,P=0.000)、병변루급교뇌여부(x2=17.585,P=0.000)、영상학분형(x2=21.247,P=0.000)시영향환자생존적인소.결론 3DCRT시뇌간효질류유효적치료방법,인동발병、병변침습교뇌、미산형이급Karnofsky평분＜80분시예후불량적위험인소.
Objective To analyse the survival time and related factors of patients with brain stem glioma who received 3DCRT.Methods Thirty-six patients with brain stem tumor were admitted from October 2004 to December 2008 and all received 3D-CRT with the dosage (50-54 Gy,25-30 f,5-6 weeks).During treatment,the patients’ outcomes were analyzed by observing the changes of symptoms,signs and adverse radiotherapy reaction and all of them were followed-up in the next 3 years.The survival data were analyzed by Kaplan-Meire method.Results The median survival time was 9 months in the 23 pediatric patients and 15 months in 13 adult patients.One-,two-and three-year survival rates between pediatric group and the adult group were 43.5 ％ (10/13) vs 76.9 ％ (10/13),26.1％ (6/23) vs 46.2 ％ (6/13),8.7 ％ (2/23) vs 38.5 ％ (5/13).Karnofsky performance scale score at admission (x2 =20.059,P =0.000),tumor site (x2 =17.585,P =0.000),growth pattern (x2 =21.247,P =0.000) were associate with survival time.Conclusion 3DCRT is an effective therapy to brain stem glioma,childhood onset,pontine glioma,diffusion style and Karnofsky performance scale less than 80 are risk factors of poor prognosis.