CAJ | 학술논문

目的:探讨醛固酮合成酶(CYP11B2)基因-344T/C多态性与高血压病血瘀证(EH-BSS)的关系.方法:收集高血压病血瘀证(EH-BSS)患者532例,高血压病非血瘀证298组(EH-non-BSS),血压正常对照者512例(Control),抽外周静脉血提取DNA,采用聚合酶链反应-限制性内切酶片段长度多态性(PCR-RFLP)检测CYP11B2基因-344T/C多态性类型.结果:卡方分割后重度EH-BSS组的TC+CC频率(55.23%)高于轻度EH-BSS组(46.83%)、EH-non-BSS组(45.30%)、Control组(43.16%),有统计学意义(X2=7.489,P=0.006).多因素Logistic回归调整混杂因素后,以EH-non-BSS组为参照系,CYP11B2-TC/CC型患重度EH-BSS的的相对危险度(OR值)为1.589(95%CI:1.035-2.440,P=0.034).结论:携带有CYP11B2-TC/CC基因型可能是重度EH-BSS易患因素之一.
목적:탐토철고동합성매(CYP11B2)기인-344T/C다태성여고혈압병혈어증(EH-BSS)적관계.방법:수집고혈압병혈어증(EH-BSS)환자532례,고혈압병비혈어증298조(EH-non-BSS),혈압정상대조자512례(Control),추외주정맥혈제취DNA,채용취합매련반응-한제성내절매편단장도다태성(PCR-RFLP)검측CYP11B2기인-344T/C다태성류형.결과:잡방분할후중도EH-BSS조적TC+CC빈솔(55.23%)고우경도EH-BSS조(46.83%)、EH-non-BSS조(45.30%)、Control조(43.16%),유통계학의의(X2=7.489,P=0.006).다인소Logistic회귀조정혼잡인소후,이EH-non-BSS조위삼조계,CYP11B2-TC/CC형환중도EH-BSS적적상대위험도(OR치)위1.589(95%CI:1.035-2.440,P=0.034).결론:휴대유CYP11B2-TC/CC기인형가능시중도EH-BSS역환인소지일.