CAJ | 학술논문

探测生物节律的周期是当今时间生物学研究的热点问题之一,它的研究将有助于了解某些病变机理和时钟基因对生物体的作用,指导临床适时用药和治疗等.介绍了Lomb-Scargle周期图、基于余弦法的谱分析方法(百分节律谱方法、倒椭圆谱方法等)、最大熵谱分析方法等几种探测生物节律周期的新方法,对各种方法的优缺点进行了探讨,并对将来的研究提出了一些建议.这些方法为准确探测生物节律的周期、揭示生物节律的变化规律提供了新的思路.
탐측생물절률적주기시당금시간생물학연구적열점문제지일,타적연구장유조우료해모사병변궤리화시종기인대생물체적작용,지도림상괄시용약화치료등.개소료Lomb-Scargle주기도、기우여현법적보분석방법(백분절률보방법、도타원보방법등)、최대적보분석방법등궤충탐측생물절률주기적신방법,대각충방법적우결점진행료탐토,병대장래적연구제출료일사건의.저사방법위준학탐측생물절률적주기、게시생물절률적변화규률제공료신적사로.
The period detection of the biological rhythms is one ofthe hot topics in the research of chronobiology,which will help to understand the mechanism of pathological changes and how the function of the clock genes affect the organism and thus guide clinical drug administration and treatment timely.Some new methods for detecting the periods of the biological rhythms,including Lomb-Scargle periodogram,spectral analysis based on Cosinor method(e.g.Percent Rhythm Spectrum and Reverse EHiptie Spectrum),and the Maximum Entropy Spectral Analysis(MESA),ale introduced in this paper.Advantages and disadvantages of the methods ale reviewed and some suggestions to the research in the future are also proposed.These methods provide promising approaches for detecting the precise periods of the biological rhythms and discovering the rule of the changes of the biological rhythms.