CAJ | 학술논문

慢性阻塞性肺疾病(chronic obstructive pneumonia discase,COPD)是以不完全可逆的气流受限为特征的慢性炎症性疾病.中性粒细胞可能在COPD的发展过程中发挥主要作用.活化的中性粒细胞释放蛋白酶、活性氧和细胞因子,引起肺组织损伤,最终导致气道黏液高分泌,气流受限和肺气肿.
만성조새성폐질병(chronic obstructive pneumonia discase,COPD)시이불완전가역적기류수한위특정적만성염증성질병.중성립세포가능재COPD적발전과정중발휘주요작용.활화적중성립세포석방단백매、활성양화세포인자,인기폐조직손상,최종도치기도점액고분비,기류수한화폐기종.
Chronic obstructive pulmonary disease(COPD)is a chronic inflammatory condition characterized by irreversible airflow limitation.Neutrophils are likely to play a major role in the progression of COPD.Activated neutrophils release neutrophil elastases,reactive oxygen species and cytokines which result in lung tissue damage.Finally,this leads to mucus hypersecretion,airflow limitation and emphysema.