中国临床实用医学
中國臨床實用醫學
중국림상실용의학
CHINA CLINICAL PRACTICAL MEDICINE
2009年
8期
6-8
,共3页
张还珠%董伟华%刘芯%黄振倩%谭获
張還珠%董偉華%劉芯%黃振倩%譚穫
장환주%동위화%류심%황진천%담획
乳腺癌%CD44v6%生物学特性
乳腺癌%CD44v6%生物學特性
유선암%CD44v6%생물학특성
Breast cancer%CD44v6%Biological characteristics
目的 探讨粘附分子CD44v6的表达情况及其与乳腺癌相关生物学特性的关系.方法 用免疫组织化学法检测本院2006年收治的65例乳腺癌女患者的病理标本CD44v6表达,并评价肿瘤相关生物学特性的情况.结果 65例乳腺癌患者中CD44v6呈阳性反应有53例,占81.5%;有腋窝淋巴结转移的病例CD44v6阳性率(90.9%)明显高于无腋窝淋巴结转移病例CD44v6阳性率(61.9%)(P＜0.01);Ki-67表达阳性患者其CD44v6阳性率为76.9%,Ki-67表达阴性患者无CD44v6阳性表达(P＜0.01);CD44v6表达的多元logistic回归分析显示:腋窝淋巴结转移情况(OR=1.604)和Ki-67表达(OR=2.800)是CD44v6表达的主要影响因素.结论 CD44v6的表达与腋窝淋巴转移情况及Ki-67表达情况密切相关,CD44v6是检测乳腺癌病情和判断预后的一个重要指标.
目的 探討粘附分子CD44v6的錶達情況及其與乳腺癌相關生物學特性的關繫.方法 用免疫組織化學法檢測本院2006年收治的65例乳腺癌女患者的病理標本CD44v6錶達,併評價腫瘤相關生物學特性的情況.結果 65例乳腺癌患者中CD44v6呈暘性反應有53例,佔81.5%;有腋窩淋巴結轉移的病例CD44v6暘性率(90.9%)明顯高于無腋窩淋巴結轉移病例CD44v6暘性率(61.9%)(P＜0.01);Ki-67錶達暘性患者其CD44v6暘性率為76.9%,Ki-67錶達陰性患者無CD44v6暘性錶達(P＜0.01);CD44v6錶達的多元logistic迴歸分析顯示:腋窩淋巴結轉移情況(OR=1.604)和Ki-67錶達(OR=2.800)是CD44v6錶達的主要影響因素.結論 CD44v6的錶達與腋窩淋巴轉移情況及Ki-67錶達情況密切相關,CD44v6是檢測乳腺癌病情和判斷預後的一箇重要指標.
목적 탐토점부분자CD44v6적표체정황급기여유선암상관생물학특성적관계.방법 용면역조직화학법검측본원2006년수치적65례유선암녀환자적병리표본CD44v6표체,병평개종류상관생물학특성적정황.결과 65례유선암환자중CD44v6정양성반응유53례,점81.5%;유액와림파결전이적병례CD44v6양성솔(90.9%)명현고우무액와림파결전이병례CD44v6양성솔(61.9%)(P＜0.01);Ki-67표체양성환자기CD44v6양성솔위76.9%,Ki-67표체음성환자무CD44v6양성표체(P＜0.01);CD44v6표체적다원logistic회귀분석현시:액와림파결전이정황(OR=1.604)화Ki-67표체(OR=2.800)시CD44v6표체적주요영향인소.결론 CD44v6적표체여액와림파전이정황급Ki-67표체정황밀절상관,CD44v6시검측유선암병정화판단예후적일개중요지표.
Objective To investigate the correlative relationship between the expression of adhesion molecule CD44v6 and biological characteristics of breast cancer.Methods Using immunhistochemical techniques,we examined the expression of CD44v6 in 65 specimens of breast cancer patients,who were diagnosed in our hospital in 2006,and assessed about biological characteristics of the tumor.Results Fifty-three of sixty-five (81.5%) women with breast carcinoma were CD44v6 positive.The positive rate of CD44v6 in cases with metastases of axillary nodes was significantly higher than that without metastases of axillary nodes (90.9% vs 61.9%,P＜0.01).The positive rate of CD44v6 in cases with Ki-67 expression was 76.9%,and there is no expression of CD44v6 in cases of Ki-67 negative (P＜0.01).In multivariate analysis,using the Logistic model,the main factors on CD44v6 expression were metastases of axillary nodes (OR=1.604) and Ki-67 expression (OR =2.800).Conclusion CD44v6 expression was closely correlated with metastases of axillary nodes and Ki-67 expression.It is an important indicator of detecting patient's condition and predicting patient's prognosis in breast cancer.
