中华放射学杂志
中華放射學雜誌
중화방사학잡지
Chinese Journal of Radiology
2012年
4期
350-353
,共4页
张靖%李海波%周少毅%陈昆山%牛传强%谭小云%蒋贻洲%林雀卿
張靖%李海波%週少毅%陳昆山%牛傳彊%譚小雲%蔣貽洲%林雀卿
장정%리해파%주소의%진곤산%우전강%담소운%장이주%림작경
儿童%血管瘤%硬化疗法%硬化溶液%乙醇%平阳霉素
兒童%血管瘤%硬化療法%硬化溶液%乙醇%平暘黴素
인동%혈관류%경화요법%경화용액%을순%평양매소
Child%Hemangioma%Sclerotherapy%Sclerosing solutions%Ethanol%Bleomycin A5
目的 比较无水乙醇碘油混合液与平阳霉素碘油混合液介入硬化治疗儿童静脉畸形的疗效和安全性.方法 2009年2月至2011年5月期间,对80例临床诊断为静脉畸形的患儿进行全麻下介入硬化治疗.80例患儿按照数字表法随机分为A、B组,每组40例.A组行无水乙醇碘油混合液治疗,B组行平阳霉素碘油混合液治疗.术后随访6 ~ 24个月,比较两组疗效及不良反应的发生率.疗效评价分为4级:治愈、基本治愈、有效、无效,治愈、基本治愈、有效的总例数为治疗有效例数.两组患儿的有效率和不良反应发生率采用x2检验比较.结果 A组治疗有效率为95.0%(38/40),B组治疗有效率为65.0%(26/40),差异有统计学意义(x2=11.25,P<0.01).不良反应:A组8例皮肤破溃、4例瘤体肿胀、2例肌肉纤维化、1例并发脑梗死;B组2例术后出现发热及呕吐,2例皮肤破溃,两者不良反应发生率差异有统计学意义(x2=12.29,P<0.01).结论 无水乙醇治疗儿童静脉畸形较平阳霉素疗效好,但不良反应发生率较高,其中以皮肤破溃较多见,甚至可造成严重的不良反应如脑梗死.
目的 比較無水乙醇碘油混閤液與平暘黴素碘油混閤液介入硬化治療兒童靜脈畸形的療效和安全性.方法 2009年2月至2011年5月期間,對80例臨床診斷為靜脈畸形的患兒進行全痳下介入硬化治療.80例患兒按照數字錶法隨機分為A、B組,每組40例.A組行無水乙醇碘油混閤液治療,B組行平暘黴素碘油混閤液治療.術後隨訪6 ~ 24箇月,比較兩組療效及不良反應的髮生率.療效評價分為4級:治愈、基本治愈、有效、無效,治愈、基本治愈、有效的總例數為治療有效例數.兩組患兒的有效率和不良反應髮生率採用x2檢驗比較.結果 A組治療有效率為95.0%(38/40),B組治療有效率為65.0%(26/40),差異有統計學意義(x2=11.25,P<0.01).不良反應:A組8例皮膚破潰、4例瘤體腫脹、2例肌肉纖維化、1例併髮腦梗死;B組2例術後齣現髮熱及嘔吐,2例皮膚破潰,兩者不良反應髮生率差異有統計學意義(x2=12.29,P<0.01).結論 無水乙醇治療兒童靜脈畸形較平暘黴素療效好,但不良反應髮生率較高,其中以皮膚破潰較多見,甚至可造成嚴重的不良反應如腦梗死.
목적 비교무수을순전유혼합액여평양매소전유혼합액개입경화치료인동정맥기형적료효화안전성.방법 2009년2월지2011년5월기간,대80례림상진단위정맥기형적환인진행전마하개입경화치료.80례환인안조수자표법수궤분위A、B조,매조40례.A조행무수을순전유혼합액치료,B조행평양매소전유혼합액치료.술후수방6 ~ 24개월,비교량조료효급불량반응적발생솔.료효평개분위4급:치유、기본치유、유효、무효,치유、기본치유、유효적총례수위치료유효례수.량조환인적유효솔화불량반응발생솔채용x2검험비교.결과 A조치료유효솔위95.0%(38/40),B조치료유효솔위65.0%(26/40),차이유통계학의의(x2=11.25,P<0.01).불량반응:A조8례피부파궤、4례류체종창、2례기육섬유화、1례병발뇌경사;B조2례술후출현발열급구토,2례피부파궤,량자불량반응발생솔차이유통계학의의(x2=12.29,P<0.01).결론 무수을순치료인동정맥기형교평양매소료효호,단불량반응발생솔교고,기중이피부파궤교다견,심지가조성엄중적불량반응여뇌경사.
Objective To evaluate and compare the curative effect and the safety of sclerotherapy of venous malformation in children using absolute ethanol and pingyangmycin.Methods Eighty children with venous malformation were treated by sclerotherapy with absolute ethanol or pingyangmycin under general anesthesia during February of 2009 to May of 2011. Diagnostic criteria included the presence of a bluecolored lesion at birth,with gradual increase in its size associated with a positive postural test.MRI showed characteristic imaging features.Eighty patients were divided into two groups by randomization.Forty patients were treated with absolute ethanol,and the remaining 40 patients with pingyangmycin. The therapeutic effects and side effects were observed and recorded during a follow-up period of 6 to 24 months ( average 15 months).Treatment results were divided into four categories: cure, basic cure, effective, and ineffective,and the former three categories were considered effective in treatment.Chi-square test was used to compare the rate of effective treatment and rate of complications in these two groups.Results The effective patients treated with absolute ethanol was 38 (95.0%,38/40),and the effective patients with pingyangmycin was 26(65.0%,26/40),x2 test ( x2 =11.25,P < 0.01 ) difference was statistically significant.Eight patients developed skin necrosis; 4 patients serious local swelling,2 patients muscle fibrosis,1 patient cerebral embolism in the absolute alcohol group.Two patients developed postoperative fever and vomiting and 2 skin necrosis in the pingyangmycin group,the difference was statistically significant (x2 =12.29,P <0.01 ). Conclusions Sclerotherapy is effective for the treatment of venous malformations in children.Absolute ethanol is more effective,but associated with more complications,such as skin necrosis or as serious as cerebral embolism,than pingyangmycin.