CAJ | 학술논문

目的探讨贲门癌高、低发区幽门螺杆菌(Hp)感染与贲门癌变的关系.方法于贲门癌高、低发区分别选择262例贲门癌患者取外周全血,利用胃Hp检测试条检测Hp感染情况并进行分析.结果贲门癌高、低发区贲门癌患者Hp感染率分别为49%、48%.高、低发区贲门癌患者Hp感染率男女分别为64%、36%和92%、8%,两者比较差异均有统计学意义(P均＜0.05),高、低发区贲门癌患者Hp感染率随年龄增长均明显增高(P＜0.05),50～70岁为发病高峰年龄;高发区贲门癌家族史阳性患者Hp感染率明显高于低发区贲门癌家族史阳性患者,低发区贲门癌家族史阳性患者Hp感染率明显低于贲门癌家族史阴性患者Hp感染率(P＜0.05).结论 Hp感染可能与贲门癌的发生、发展有一定关系,Hp感染率高的人群贲门癌易感性较低.
목적 탐토분문암고、저발구유문라간균(Hp)감염여분문암변적관계.방법 우분문암고、저발구분별선택262례분문암환자취외주전혈,이용위Hp검측시조검측Hp감염정황병진행분석.결과 분문암고、저발구분문암환자Hp감염솔분별위49%、48%.고、저발구분문암환자Hp감염솔남녀분별위64%、36%화92%、8%,량자비교차이균유통계학의의(P균＜0.05),고、저발구분문암환자Hp감염솔수년령증장균명현증고(P＜0.05),50～70세위발병고봉년령;고발구분문암가족사양성환자Hp감염솔명현고우저발구분문암가족사양성환자,저발구분문암가족사양성환자Hp감염솔명현저우분문암가족사음성환자Hp감염솔(P＜0.05).결론 Hp감염가능여분문암적발생、발전유일정관계,Hp감염솔고적인군분문암역감성교저.
Objective To further elucidate the possible relationship between infection of Helicobacter pylori(Hp)and gastric cardia carcinogenesis on the subjects from HIA and LIA for GCC.Methods Helicobacter pylori Kit were undertaken to determine the expression of Hp in gastric cardia carcinogenesis.Two hundred and sixty -two surgical resected GCA specimens were selected randomly from the hospital(161 from the HIA, 101 from the LIA).Results The ratio of Hp infection of the gastric - cardia adenocarcinoma was 49% and 48% in high and low - incidence areas for gastric cardia carcinogenesis (P ＞ 0.05).However, in high and low - incidence area, the rate of Hp infectiion of GCA in male was higher than in females and the older was higher than the young.The ratio of Hp infection of FH(+)in high - incidence area was apparently higher than that in the low - incidence area.However, in the LIA,the rate of Hp infection of FH(+)was apparently higher than the Hp infection of FH(-), P ＜ 0.05.Conclusions The affectability of GCA of Hp infection is low.Hp infection is correlated with the carcinogenesis and development of cardiac cancer in high and low - incidence area.