CAJ | 학술논문

背景:最近研究结果证实,肿瘤中存在一小部分肿瘤干细胞,肿瘤干细胞兼有成体干细胞和胚胎干细胞的自我更新和多能性特征,在肿瘤发展中起重要作用.血管内皮生长因子可调节内皮增殖、血管生成,调节血管通透性及血栓形成.目的:文章就肿瘤干细胞与肿瘤血管生成的研究进展做一综述.方法:应用计算机检索Pubmed数据库(2000-01/2009-10),以"Cancer stem cells,Vascular endothelial growth factor,New vascularize"为检索训:同时应用计算机检索CNKI数据库(2000-01/2009-10)和万方数据库(2000-01/2009-10),以"肿瘤十细胞血、管内皮生长因子、新生血管化"为检索词.结果与结论:计算机初检得到153篇,中文13篇,英文140篇.阅读标题和摘要进行初筛,排除因研究目的与此文无关的35篇,内容重复性文献30篇,Meta分析57篇,共保留31篇做进一步分析.由多种因素调控的血管新生是肿瘤生长和转移过程中的必需环节,干细胞参与并促进肿瘤血管新生,从而促进肿瘤的生长和转移,而修饰后的干细胞则可以起到反向的作用.同时,干细胞也可以作为治疗物质的载体定位肿瘤病灶,特别是在寻找亚临床病灶及远处转移病灶方面具有潜在的优越性.
배경:최근연구결과증실,종류중존재일소부분종류간세포,종류간세포겸유성체간세포화배태간세포적자아경신화다능성특정,재종류발전중기중요작용.혈관내피생장인자가조절내피증식、혈관생성,조절혈관통투성급혈전형성.목적:문장취종류간세포여종류혈관생성적연구진전주일종술.방법:응용계산궤검색Pubmed수거고(2000-01/2009-10),이"Cancer stem cells,Vascular endothelial growth factor,New vascularize"위검색훈:동시응용계산궤검색CNKI수거고(2000-01/2009-10)화만방수거고(2000-01/2009-10),이"종류십세포혈、관내피생장인자、신생혈관화"위검색사.결과여결론:계산궤초검득도153편,중문13편,영문140편.열독표제화적요진행초사,배제인연구목적여차문무관적35편,내용중복성문헌30편,Meta분석57편,공보류31편주진일보분석.유다충인소조공적혈관신생시종류생장화전이과정중적필수배절,간세포삼여병촉진종류혈관신생,종이촉진종류적생장화전이,이수식후적간세포칙가이기도반향적작용.동시,간세포야가이작위치료물질적재체정위종류병조,특별시재심조아림상병조급원처전이병조방면구유잠재적우월성.
BACKGROUND:Recent investigations show that there are a small part of self-renewing and multi-potent cells named as tumor stem cells.Those cells share many characteristics with somatic and embryonic stem cells and are thought to be responsible for driving tumor progression in growing list of neoplastic diseases.Vascular endothelial growth factor(VEGF)is an important angiogenesis factor,which can regulate endothelial proliferation,angiogenesis,permeability of blood vessel,and thrombogenesis.OBJECTIVE:To summarize the progress of cancer stem cells and tumor angiogenesis.METHODS:A computer-based online search was conducted in PUMMED,CNKI,and Wanfang databases with the key words of "cancer stem cells,vascular endothelial growth factor,new vascularize" in both Chinese and English from January 2000 to October 2009.RESULTS AND CONCLUSION:Among 153 articles,there were 13 in Chinese and 140 in English.Titles and abstracts were preliminarily screened,and articles which were non-relative(n=35),duplicated(n=30),and Meta analysis(n=57),were excluded.A total of 31 articles were included in the final analysis.Angiogenesis regulated by multiple factors was a necessary link for tumor growth and transferring.Stem cells promoted angiogenesis,thereby promoted tumor growth and transferring.However,the modified stem cells caused the opposite effects.On the other hand,the stem cells were considered as a substance vector to localize tumor focus,in particular,it will be potential for looking for subclinical focus and distal focus.