CAJ | 학술논문

对人尿道致病性大肠杆菌(uropathogenic Escherichia coli,UPEC)HEC4株和禽致病性大肠杆菌(avian pathogenic Escherichia coli,APEC)E058株进行毒力基因和其他相关特性的比较,结果显示,它们具有一些共同的毒力基因,包括一些存在于APEC中一个大的可传递质粒上的基因;同时,它们也具有一些相似的生化特性.对SPF鸡的致病性试验显示,这两株分离株具有相似的致病力.因此,对于APEC和UPEC的相关性,以及APEC是否有可能导致人尿道感染或者成为UPEC的毒力基因贮主,有待进一步研究.
대인뇨도치병성대장간균(uropathogenic Escherichia coli,UPEC)HEC4주화금치병성대장간균(avian pathogenic Escherichia coli,APEC)E058주진행독력기인화기타상관특성적비교,결과현시,타문구유일사공동적독력기인,포괄일사존재우APEC중일개대적가전체질립상적기인;동시,타문야구유일사상사적생화특성.대SPF계적치병성시험현시,저량주분리주구유상사적치병력.인차,대우APEC화UPEC적상관성,이급APEC시부유가능도치인뇨도감염혹자성위UPEC적독력기인저주,유대진일보연구.
Since avian pathogenic Escherichia coli (APEC) and human uropathogenic Escherichia coli (UPEC) may encounter similar challenges when establishing infection in the extra-intestinal locations of the hosts, they may share a similar content of virulence genes and capacity to cause disease. One APEC and one UPEC isolates were compared by their content of virulence genes and other traits. The two strains showed overlap in terms of their virulence genotypes, including their possession of certain genes associated with a large transmissible plasmid of APEC,and also shared some biochemical activities. Study of the pathogenicity of UPEC in chicks showed the similar symptoms and lesions compare to those caused by APEC. Based on these results, the potential whether APEC might serve as a reservoir of plasmid-linked and virulence genes for UPEC should be considered.