国际放射医学核医学杂志
國際放射醫學覈醫學雜誌
국제방사의학핵의학잡지
INTERNATIONAL JOURNAL OF RADIATION MEDICINE AND NUCLEAR MEDICINE
2011年
1期
31-34
,共4页
邵小南%王跃涛%王小松%陈海龙
邵小南%王躍濤%王小鬆%陳海龍
소소남%왕약도%왕소송%진해룡
肾肿瘤%肾小球滤过率%99m锝五乙酸盐%体层摄影术,发射型计算机,单光子
腎腫瘤%腎小毬濾過率%99m锝五乙痠鹽%體層攝影術,髮射型計算機,單光子
신종류%신소구려과솔%99m득오을산염%체층섭영술,발사형계산궤,단광자
Kidney neoplasms%Glomerular filtration rate%Technetium Tc 99m pentetate%Tomography,emission-computed,single-photon
目的 探讨99Tcm-DTPA法肾小球滤过率(GFR)在肾细胞癌(RCC)患者术前肾功能评价中的临床意义.方法 99例RCC患者,其中行根治性肾切除术(RN)者89例,行保留肾手术(NSS)者10例.术前行99Tcm-二亚乙基三胺五乙酸(99Tcm-DTPA)显像测定GFR.比较RCC患者和对照组(正常供肾者)的GFR差异以及RN组和NSS组患者的GFR差异,并比较GFR和血肌酐、尿素氮在评价RCC患者术前肾功能异常中的差异.统计学方法采用t检验和X2检验.结果 RCC患者双肾GFR[(76.4±20.4)ml/min]低于对照组[(80.6±17,4)ml/min],但二者差异无统计学意义(t=0.650,P>0.05).19例(19.2%)RCC患者术前存在肾功能异常(双肾GFR<60 ml/min),而血肌酐异常(>133 μmol/L)者仅4例.RCC患者中,NSS组患侧肾脏GFR与RN组相比,差异无统计学意义[(34.1±11.7)ml/min vs.(37.9±11.9)ml/min,t=0.975,P>0.05],对侧肾脏GFR低于RN组[(32.7±10.3)ml/min vs.(39.6±10.1)ml/min,t=0.044,P<0.05],NSS组术前肾功能异常者比例明显高于RN组(50.0%vs.15.7%,X2=6.808,P<0.01 )结论 99Tcm-DTPA法测定的GFR能获得RCC患者术前双肾和分肾功能的准确信息,对RCC患者的治疗决策有重要意义.
目的 探討99Tcm-DTPA法腎小毬濾過率(GFR)在腎細胞癌(RCC)患者術前腎功能評價中的臨床意義.方法 99例RCC患者,其中行根治性腎切除術(RN)者89例,行保留腎手術(NSS)者10例.術前行99Tcm-二亞乙基三胺五乙痠(99Tcm-DTPA)顯像測定GFR.比較RCC患者和對照組(正常供腎者)的GFR差異以及RN組和NSS組患者的GFR差異,併比較GFR和血肌酐、尿素氮在評價RCC患者術前腎功能異常中的差異.統計學方法採用t檢驗和X2檢驗.結果 RCC患者雙腎GFR[(76.4±20.4)ml/min]低于對照組[(80.6±17,4)ml/min],但二者差異無統計學意義(t=0.650,P>0.05).19例(19.2%)RCC患者術前存在腎功能異常(雙腎GFR<60 ml/min),而血肌酐異常(>133 μmol/L)者僅4例.RCC患者中,NSS組患側腎髒GFR與RN組相比,差異無統計學意義[(34.1±11.7)ml/min vs.(37.9±11.9)ml/min,t=0.975,P>0.05],對側腎髒GFR低于RN組[(32.7±10.3)ml/min vs.(39.6±10.1)ml/min,t=0.044,P<0.05],NSS組術前腎功能異常者比例明顯高于RN組(50.0%vs.15.7%,X2=6.808,P<0.01 )結論 99Tcm-DTPA法測定的GFR能穫得RCC患者術前雙腎和分腎功能的準確信息,對RCC患者的治療決策有重要意義.
목적 탐토99Tcm-DTPA법신소구려과솔(GFR)재신세포암(RCC)환자술전신공능평개중적림상의의.방법 99례RCC환자,기중행근치성신절제술(RN)자89례,행보류신수술(NSS)자10례.술전행99Tcm-이아을기삼알오을산(99Tcm-DTPA)현상측정GFR.비교RCC환자화대조조(정상공신자)적GFR차이이급RN조화NSS조환자적GFR차이,병비교GFR화혈기항、뇨소담재평개RCC환자술전신공능이상중적차이.통계학방법채용t검험화X2검험.결과 RCC환자쌍신GFR[(76.4±20.4)ml/min]저우대조조[(80.6±17,4)ml/min],단이자차이무통계학의의(t=0.650,P>0.05).19례(19.2%)RCC환자술전존재신공능이상(쌍신GFR<60 ml/min),이혈기항이상(>133 μmol/L)자부4례.RCC환자중,NSS조환측신장GFR여RN조상비,차이무통계학의의[(34.1±11.7)ml/min vs.(37.9±11.9)ml/min,t=0.975,P>0.05],대측신장GFR저우RN조[(32.7±10.3)ml/min vs.(39.6±10.1)ml/min,t=0.044,P<0.05],NSS조술전신공능이상자비례명현고우RN조(50.0%vs.15.7%,X2=6.808,P<0.01 )결론 99Tcm-DTPA법측정적GFR능획득RCC환자술전쌍신화분신공능적준학신식,대RCC환자적치료결책유중요의의.
Objective To investigate the clinical significance of glomerular filtration rate(GFR)measured by 99Tcm-diethylenetriamine pentaacetic acid(99Tcm-DTPA)renal dynamic imaging in renal cell carcinoma(RCC)patients before surgery.Methods There were 99 cases of RCC patients,89 patients undergoing radical nephrectomy(RN)and 10 patients undergoing nephron-sparing surgery(NSS).99Tcm-DTPA renal dynamic imaging was performed for determining GFR before surgery.Make a comparison of GFR between RCC group and control group (normal kidney donors),RN group and NSS group.Make a comparison between GFR and serum creatinine in determining preoperative renal dysfunction of RCC patients.All of the data were analyzed by t-test and X2-text.Results Compared with contral group,total GFR of RCC patients was lower,but there was no significant difference[(76.4±20.4)ml/min vs.(80.6±17.4)ml/min,t=0.650,P>0.05)].Nineteen cases(19.2%)of RCC patients had preoperative renal dysfunction(total GFR<60 ml/min),but only 4 cases performed abnormal serum creatinine(>133μmol/L).There was no significant difference in GFR of neoplastic kidneys between RN group and NSS group[(34.1±11.7)ml/min vs.(37.9±11.9)ml/min,t=0.975,P>0.05].GFR of contralateral kidneys was lower in NSS group than RN group[(32.7±10.3)ml/min vs.(39.6±10.1)ml/min,t=0.044,P<0.05].The percentage of preoperative renal dysfunction(total GFR<60 ml/min)in NSS group was significantly higher than in RN group(50.0% vs.15.7%,X2=6.808,P<0.01).Conclusion GFR can provide the accurate information of both kidneys and single kidney before surgery,and this result possessed an important significance in choice of treatments.
