CAJ | 학술논문

人抗原R(HuR)广泛分布于哺乳动物体内，主要分布于细胞核，在低氧、应激、紫外线等刺激下，可与多种富含AU序列的mRNA结合，增加了mRNA的稳定性。HuR可被p38 MAPK-MK2、AMPK和PKC等多条信号通路调节，参与细胞周期、增殖、分化及炎症反应等。在肺的急性炎症反应中，HuR可以和多种炎症因子mRNA结合，如肿瘤坏死因子α、白介素19和白介素8等，影响了mRNA稳定性和蛋白表达。敲除HuR后，炎症因子的mRNA及蛋白表达量均明显减少，表明HuR在急性肺损伤中起了重要作用。
인항원R(HuR)엄범분포우포유동물체내，주요분포우세포핵，재저양、응격、자외선등자격하，가여다충부함AU서렬적mRNA결합，증가료mRNA적은정성。HuR가피p38 MAPK-MK2、AMPK화PKC등다조신호통로조절，삼여세포주기、증식、분화급염증반응등。재폐적급성염증반응중，HuR가이화다충염증인자mRNA결합，여종류배사인자α、백개소19화백개소8등，영향료mRNA은정성화단백표체。고제HuR후，염증인자적mRNA급단백표체량균명현감소，표명HuR재급성폐손상중기료중요작용。
Human antigen R (HuR) is widely distributed in mammals, mainly in the nucleus. HuR can bind to AU-rich elements-containing mRNAs under hypoxia, stress and ultraviolet ray stimulation,and increase the stability of target mRNAs. p38 MAPK-MK2, AMPK and PKC are involved in regulating HuR, which plays an important role in cycle regulation, proliferation, differentiation and inflammation.In acute lung inflammation, HuR can bind to the mRNAs of tumor necrosis factor-a, interleukin-19 and interleukin-8 and affect the mRNA stability and the corresponding protein production. HuR knockdown reduces the levels of mRNA and protein expression of inflammatory factors, which shows that HuR plays an important role in acute lung injury.