中国医药
中國醫藥
중국의약
CHINA MEDICINE
2010年
11期
989-990
,共2页
脑梗塞%白细胞介素6%白细胞介素8
腦梗塞%白細胞介素6%白細胞介素8
뇌경새%백세포개소6%백세포개소8
Acute cerebral infarction%Interleukin-6%Interleukin-8
目的 观察急性脑梗死患者血清白细胞介素6(IL-6)、IL-8水平的变化及其意义. 方法 采用免疫酶联吸附法检测90例急性脑梗死患者(急性脑梗死组)与30名健康人(对照组)的血清IL-6和IL-8水平,并按临床神经功能缺损程度评分标准对急性脑梗死患者进行评分,分组比较. 结果 急性脑梗死组血清IL-6和IL-8水平分别为(47.45±15.89)、(57.73±43.88)ng/L,明显高于对照组[分别为(8.93±1.87)、(12.30±2.50)ng/L,P＜0.01],重型神经功能缺损患者(20例)血清IL-6和IL-8水平分别为(78.45±28.34)、(88.6±10.9)ng/L,明显高于中型(36例)、轻型(34例)患者[中型为(41.56±14.34)、(55.20±5.90)ng/L,轻型为(25.78±12.34)、(34.30±8.90)ng/L],均P＜0.05],中型神经功能缺损患者血清IL-6和IL-8水平明显高于轻型(P＜0.05). 结论 急性脑梗死患者血清IL-6和IL-8水平明显增高,血清IL-6和IL-8升高的程度与神经功能缺损程度密切相关.
目的 觀察急性腦梗死患者血清白細胞介素6(IL-6)、IL-8水平的變化及其意義. 方法 採用免疫酶聯吸附法檢測90例急性腦梗死患者(急性腦梗死組)與30名健康人(對照組)的血清IL-6和IL-8水平,併按臨床神經功能缺損程度評分標準對急性腦梗死患者進行評分,分組比較. 結果 急性腦梗死組血清IL-6和IL-8水平分彆為(47.45±15.89)、(57.73±43.88)ng/L,明顯高于對照組[分彆為(8.93±1.87)、(12.30±2.50)ng/L,P＜0.01],重型神經功能缺損患者(20例)血清IL-6和IL-8水平分彆為(78.45±28.34)、(88.6±10.9)ng/L,明顯高于中型(36例)、輕型(34例)患者[中型為(41.56±14.34)、(55.20±5.90)ng/L,輕型為(25.78±12.34)、(34.30±8.90)ng/L],均P＜0.05],中型神經功能缺損患者血清IL-6和IL-8水平明顯高于輕型(P＜0.05). 結論 急性腦梗死患者血清IL-6和IL-8水平明顯增高,血清IL-6和IL-8升高的程度與神經功能缺損程度密切相關.
목적 관찰급성뇌경사환자혈청백세포개소6(IL-6)、IL-8수평적변화급기의의. 방법 채용면역매련흡부법검측90례급성뇌경사환자(급성뇌경사조)여30명건강인(대조조)적혈청IL-6화IL-8수평,병안림상신경공능결손정도평분표준대급성뇌경사환자진행평분,분조비교. 결과 급성뇌경사조혈청IL-6화IL-8수평분별위(47.45±15.89)、(57.73±43.88)ng/L,명현고우대조조[분별위(8.93±1.87)、(12.30±2.50)ng/L,P＜0.01],중형신경공능결손환자(20례)혈청IL-6화IL-8수평분별위(78.45±28.34)、(88.6±10.9)ng/L,명현고우중형(36례)、경형(34례)환자[중형위(41.56±14.34)、(55.20±5.90)ng/L,경형위(25.78±12.34)、(34.30±8.90)ng/L],균P＜0.05],중형신경공능결손환자혈청IL-6화IL-8수평명현고우경형(P＜0.05). 결론 급성뇌경사환자혈청IL-6화IL-8수평명현증고,혈청IL-6화IL-8승고적정도여신경공능결손정도밀절상관.
Objective To observe the changes and clinic significance of levels of serum interleukin 6(IL-6)and interleukin 8(IL-8)in patients with acute cerebral infarction. Methods The serum level of IL-6 and IL-8 of 90 patients with acute cerebral infarction and 30 healthy persons was measured by enzyme-linked immunosorbent assay(ELISA).All the patients were scored by clinic neurological function deficit scale(NDS),and comparision was made among the groups. Results The serum level of IL-6 and IL-8 of the patients was significantly higher than that of the normal control(P ＜ 0.01),and the serum level of IL-6 and IL-8 of the group with serious cerebral infarction was significantly higher than the groups with middle and mild cerebral infarction(P ＜ 0.05),the serum level of IL-6 and IL-8 of the group with middle cerebral infarction was significantly higher than the groups with mild cerebral infarction(P ＜ 0.05). Conclusions Serum levels of IL-6 and IL-8 increase markedly in patients with acute cerebral infarction.The elevation is closely related to the degree of neurological impairment.
