中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2012年
28期
24-26
,共3页
有机磷化合物%中毒%酶类%C反应蛋白质
有機燐化閤物%中毒%酶類%C反應蛋白質
유궤린화합물%중독%매류%C반응단백질
Organophosphorus compounds%Poisoning%Enzymes%C-reactive protein
目的 探索应用不同治疗方案救治急性有机磷杀虫药中毒患者的临床疗效.方法 将130例急性有机磷杀虫药中毒患者按照随机数字表法分为治疗组(80例)和对照组(50例),治疗组患者在常规治疗的基础上予以阿托品静脉注射联合氯解磷定阶梯肌肉注射进行解毒药物治疗,对照组患者在常规治疗的基础上予以阿托品静脉注射联合氯解磷定静脉滴注进行解毒药物治疗.对两组患者治愈率、肌酸激酶(CK)、天冬氨酸氨基转移酶(AST)、淀粉酶、C反应蛋白(CRP)等指标进行比较.结果 治疗组轻度、中度及重度中毒患者的治愈率分别为100.00％( 19/19)、95.35％(41/43)和88.89％(16/18),对照组轻度、中度、重度中毒患者的治愈率分别为75.00％(9/12)、64.29％(18/28)、60.00％(6/10),两组相同中毒程度患者治愈率比较差异均有统计学意义(P＜0.05).两组治疗前CK、AST、淀粉酶、CRP比较差异无统计学意义(P＞ 0.05)；治疗组治疗后CK为(152.3±23.2) U/L、AST为(37.5±11.4) U/L、淀粉酶为(114.2±43.8) U/L、CRP为(5.7±4.1)mg/L,对照组治疗后分别为(258.5±22.2) U/L、(44.5±12.4) U/L、( 147.3±61.4) U/L、(9.8±5.2) mg/L,两组比较差异有统计学意义(P＜0.05).结论 应用阿托品静脉注射联合氯解磷定阶梯肌肉注射法对于轻度、中度以及重度急性有机磷杀虫药中毒患者均具有更为优异的兼顾治疗效果,各种程度的中毒患者的临床治愈率以及血液生化指标均更为理想,值得临床推广应用.
目的 探索應用不同治療方案救治急性有機燐殺蟲藥中毒患者的臨床療效.方法 將130例急性有機燐殺蟲藥中毒患者按照隨機數字錶法分為治療組(80例)和對照組(50例),治療組患者在常規治療的基礎上予以阿託品靜脈註射聯閤氯解燐定階梯肌肉註射進行解毒藥物治療,對照組患者在常規治療的基礎上予以阿託品靜脈註射聯閤氯解燐定靜脈滴註進行解毒藥物治療.對兩組患者治愈率、肌痠激酶(CK)、天鼕氨痠氨基轉移酶(AST)、澱粉酶、C反應蛋白(CRP)等指標進行比較.結果 治療組輕度、中度及重度中毒患者的治愈率分彆為100.00％( 19/19)、95.35％(41/43)和88.89％(16/18),對照組輕度、中度、重度中毒患者的治愈率分彆為75.00％(9/12)、64.29％(18/28)、60.00％(6/10),兩組相同中毒程度患者治愈率比較差異均有統計學意義(P＜0.05).兩組治療前CK、AST、澱粉酶、CRP比較差異無統計學意義(P＞ 0.05)；治療組治療後CK為(152.3±23.2) U/L、AST為(37.5±11.4) U/L、澱粉酶為(114.2±43.8) U/L、CRP為(5.7±4.1)mg/L,對照組治療後分彆為(258.5±22.2) U/L、(44.5±12.4) U/L、( 147.3±61.4) U/L、(9.8±5.2) mg/L,兩組比較差異有統計學意義(P＜0.05).結論 應用阿託品靜脈註射聯閤氯解燐定階梯肌肉註射法對于輕度、中度以及重度急性有機燐殺蟲藥中毒患者均具有更為優異的兼顧治療效果,各種程度的中毒患者的臨床治愈率以及血液生化指標均更為理想,值得臨床推廣應用.
목적 탐색응용불동치료방안구치급성유궤린살충약중독환자적림상료효.방법 장130례급성유궤린살충약중독환자안조수궤수자표법분위치료조(80례)화대조조(50례),치료조환자재상규치료적기출상여이아탁품정맥주사연합록해린정계제기육주사진행해독약물치료,대조조환자재상규치료적기출상여이아탁품정맥주사연합록해린정정맥적주진행해독약물치료.대량조환자치유솔、기산격매(CK)、천동안산안기전이매(AST)、정분매、C반응단백(CRP)등지표진행비교.결과 치료조경도、중도급중도중독환자적치유솔분별위100.00％( 19/19)、95.35％(41/43)화88.89％(16/18),대조조경도、중도、중도중독환자적치유솔분별위75.00％(9/12)、64.29％(18/28)、60.00％(6/10),량조상동중독정도환자치유솔비교차이균유통계학의의(P＜0.05).량조치료전CK、AST、정분매、CRP비교차이무통계학의의(P＞ 0.05)；치료조치료후CK위(152.3±23.2) U/L、AST위(37.5±11.4) U/L、정분매위(114.2±43.8) U/L、CRP위(5.7±4.1)mg/L,대조조치료후분별위(258.5±22.2) U/L、(44.5±12.4) U/L、( 147.3±61.4) U/L、(9.8±5.2) mg/L,량조비교차이유통계학의의(P＜0.05).결론 응용아탁품정맥주사연합록해린정계제기육주사법대우경도、중도이급중도급성유궤린살충약중독환자균구유경위우이적겸고치료효과,각충정도적중독환자적림상치유솔이급혈액생화지표균경위이상,치득림상추엄응용.
Objective To explore the clinical efficacy of different treatment programs for patients with acute organophosphate poisoning (AOPP).Methods One hundred and thirty patients with AOPP were divided into treatment group (80 cases) and control group (50 cases) by table of random digit.The treatment group was given atropine intravenous injection combined with pralidoxime chloride ladder intramuscular injection on the basis of the conventional treatment.The control group was given atropine intravenous injection combined with pralidoxime chloride intravenous drip on the basis of conventional treatment.The healing rate,creatine kinase (CK),aspartate aminotransferase (AST),amylase and C-reactive protein (CRP) were compared between two groups.Results The healing rates of patients with mild,moderate and severe poisoning patients in treatment group were respectively significantly higher than those in control group [ 100.00％(19/19) vs.75.00％(9/12),95.35％(41/43) vs.64.29％(18/28) and 88.89％(16/18) vs.60.00％ (6/10),P ＜0.05].There was no significant difference in CK,AST,amylase and CRP before treatment between two groups (P ＞ 0.05).The CK,AST,amylase and CRP after treatment in treatment group were significantly lower than those in control group [ ( 152.3 ± 23.2) U/L vs.(258.5 ± 22.2) U/L,(37.5 ± 11.4) U/L vs.(44.5± 12.4) U/L,(114.2±43.8) U/Lvs.(147.3 ±61.4) U/L,(5.7±4.1)mg/Lvs.(9.8±5.2)mg/L,P ＜0.05].Conclusions The use of atropine intravenous injection combined with pralidoxime chloride ladder intramuscular injection for mild,moderate and severe AOPP patients is excellent in therapeutic effects,and the clinical cure rates and blood biochemical parameters are more desirable.It is worthy of clinical application.
