CAJ | 학술논문

目的检测胰腺癌与正常胰腺组织中nectin-4蛋白的表达水平,探讨nectin-4蛋白的表达情况与胰腺癌临床病理特征之间的关系及临床意义.方法采用免疫组织化学方法检测40例胰腺癌组织及12例正常胰腺组织中nectin-4蛋白的表达情况,并分析其与胰腺癌临床病理参数之间的关系.结果 (1)各组中nectin-4蛋白的表达水平:胰腺癌组,累积吸光度值2.43±0.75,阳性区域面积值9.73±1.86;正常胰腺组,累积吸光度值1.06±0.68,阳性区域面积值4.76±1.70.胰腺癌组织中nectin-4蛋白的阳性表达量高于后者,差异有统计学意义(P＜0.01);(2)nectin-4蛋白与胰腺癌临床病理参数的关系:在不同性别、不同年龄间比较,差异均无统计学意义(P＞0.05);与组织病理分化程度(P＜0.01)、有无淋巴结转移(P＜0.05)均明显相关.结论胰腺癌组织中nectin-4蛋白呈高表达状态,其过量表达与胰腺癌的恶性程度密切相关.
목적 검측이선암여정상이선조직중nectin-4단백적표체수평,탐토nectin-4단백적표체정황여이선암림상병리특정지간적관계급림상의의.방법 채용면역조직화학방법검측40례이선암조직급12례정상이선조직중nectin-4단백적표체정황,병분석기여이선암림상병리삼수지간적관계.결과 (1)각조중nectin-4단백적표체수평:이선암조,루적흡광도치2.43±0.75,양성구역면적치9.73±1.86;정상이선조,루적흡광도치1.06±0.68,양성구역면적치4.76±1.70.이선암조직중nectin-4단백적양성표체량고우후자,차이유통계학의의(P＜0.01);(2)nectin-4단백여이선암림상병리삼수적관계:재불동성별、불동년령간비교,차이균무통계학의의(P＞0.05);여조직병리분화정도(P＜0.01)、유무림파결전이(P＜0.05)균명현상관.결론 이선암조직중nectin-4단백정고표체상태,기과량표체여이선암적악성정도밀절상관.
Objective To investigate the expressions and the clinical significance of nectin-4 in pancreatic carcinoma and the relationship with clinicopathological features. Methods Immunohistocbemical techniques were used to detect nectin-4 expression in pancreatic carcinoma tissues (n = 40) and normal pancreatic tissues (n = 12 ), and the relationship between the expressions and clinicopathological parameters was analyzed. Results The IOD and area of nectin-4 were 2. 43 ± 0.75 and 9. 73 ± 1.86 in pancreatic carcinoma tissues, which were significantly higher than those in the normal pancreatic tissues( P ＜ 0.01 ).The expression of nectin-4 was not correlated with patients demographics ( P ＞ 0.05 ), and the protein expression was correlated with histopathologic grade ( P ＜ 0.01 ) and lymph metastasis ( P ＜ 0.05 ).Conclusions The high expression of nectin-4 in pancreatic carcinoma tissues suggests that its high expression may be correlated with the malignant degree of the carcinoma. nectin-4 can be considered as a reference index of differentiation, metastasis and prognosis in pancreatic carcinoma.