CAJ | 학술논문

Objective To investigate the effect of a new 20-crystalline aminoacids solution enriched with glutamine dipeptede and branch-chained animo acids(BCAA)on the morphological changes of the intestinal mucosa of SBS rats. Methods 32 male wistars rats were randomly allocated into 3 groups:12 rats in Gln-group,12 rats in Std-group,8 rats in Nitrogen-free group.Using the model of SBS rats,nutritional liquid with different aminoacids was given by central catheterization.The body weight,nitrogen balance,the total DNA and RNA of jejunalmucosal cells,jejunal mucosal thickness and villus height were measured. Results The results showed that all variable in 20AA group and 17AA group were better than no nitrogen(the second)group(P<0.05).The 20AA group had better body weight,nitrogen balance and jejunum morphology than 17AA group.Jejunal mucosalthickness and villus height,total DNA and RNA of jejunal mucosal cells in 20AA group was increased compared with 17AA group(P<0.05). Conclusions The result showed that 20AA TPN group had better nutritional support,passive nitrogen balance can be improved.It appears that 20AA TPN could be provided to maintain and support growth of the gestrointestinal mucose.