国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2008年
11期
983-985
,共3页
章火祥%谢鑫友%于小妹%钭春凤%王丽君
章火祥%謝鑫友%于小妹%鈄春鳳%王麗君
장화상%사흠우%우소매%두춘봉%왕려군
胶原Ⅰ型%骨钙素%肿瘤转移%交联试剂
膠原Ⅰ型%骨鈣素%腫瘤轉移%交聯試劑
효원Ⅰ형%골개소%종류전이%교련시제
Collagen type I%Osteocalcin%Neoplasm metastasis%Cross linking reagents
目的 探讨骨胶原吸收指标血清Ⅰ型胶原吡啶交联终肽(ICTP)和骨形成指标血清骨钙素(OC)二者在肿瘤骨转移的应用价值.方法 收集我院肿瘤科经病理确诊的肺癌患者血清65例,乳腺癌患者血清36例,通过影像学诊断,将其分为骨未转移组和骨转移组两组.并征集我院健康体检人群41例作为健康对照组,分别定量测定血清ICTP、OC和碱性磷酸酶(ALP)浓度.结果 血清ICTP在肺癌和乳腺癌骨转移组[(27.80±11.14)μg/L和(122.33±34.92)μg/L]均显著高于骨未转移组[(8.95±3.81)μg/L和(8.40±4.59)μg/L],差异有统计学意义(P<0 01),骨未转移组较健康对照组[(5.16±1.76)μg/L]亦有极显著性差异(P<0.01),血清OC值在乳腺癌骨转移组[(69.31±36.17)ng/mL]亦显著高于骨未转移组[(15.54±6.09)ng/mL],差异有统计学意义(P<0.01),而肺癌骨未转移组血清OC值较健康对照组以及肺癌骨转移组较肺癌骨未转移组差异均无统计学意义(P>0.05).血清ICTP在诊断肺癌和乳腺癌骨转移中是特异性高、敏感度较好的指标,血清OC在诊断肺癌骨转移中单独使用敏感度不够,意义不大,但在诊断乳腺癌骨转移时特异度和敏感度均较好.两者联合诊断乳腺癌骨转移的敏感度为96.3%,特异度为96.7%,联合诊断肺癌骨转移的敏感度为80.3%,特异度为84.2%.结论 可根据需要单独或联合应用血清ICTP和OC,作为除影像学外诊断肿瘤骨转移有用的实验室诊断指标.
目的 探討骨膠原吸收指標血清Ⅰ型膠原吡啶交聯終肽(ICTP)和骨形成指標血清骨鈣素(OC)二者在腫瘤骨轉移的應用價值.方法 收集我院腫瘤科經病理確診的肺癌患者血清65例,乳腺癌患者血清36例,通過影像學診斷,將其分為骨未轉移組和骨轉移組兩組.併徵集我院健康體檢人群41例作為健康對照組,分彆定量測定血清ICTP、OC和堿性燐痠酶(ALP)濃度.結果 血清ICTP在肺癌和乳腺癌骨轉移組[(27.80±11.14)μg/L和(122.33±34.92)μg/L]均顯著高于骨未轉移組[(8.95±3.81)μg/L和(8.40±4.59)μg/L],差異有統計學意義(P<0 01),骨未轉移組較健康對照組[(5.16±1.76)μg/L]亦有極顯著性差異(P<0.01),血清OC值在乳腺癌骨轉移組[(69.31±36.17)ng/mL]亦顯著高于骨未轉移組[(15.54±6.09)ng/mL],差異有統計學意義(P<0.01),而肺癌骨未轉移組血清OC值較健康對照組以及肺癌骨轉移組較肺癌骨未轉移組差異均無統計學意義(P>0.05).血清ICTP在診斷肺癌和乳腺癌骨轉移中是特異性高、敏感度較好的指標,血清OC在診斷肺癌骨轉移中單獨使用敏感度不夠,意義不大,但在診斷乳腺癌骨轉移時特異度和敏感度均較好.兩者聯閤診斷乳腺癌骨轉移的敏感度為96.3%,特異度為96.7%,聯閤診斷肺癌骨轉移的敏感度為80.3%,特異度為84.2%.結論 可根據需要單獨或聯閤應用血清ICTP和OC,作為除影像學外診斷腫瘤骨轉移有用的實驗室診斷指標.
목적 탐토골효원흡수지표혈청Ⅰ형효원필정교련종태(ICTP)화골형성지표혈청골개소(OC)이자재종류골전이적응용개치.방법 수집아원종류과경병리학진적폐암환자혈청65례,유선암환자혈청36례,통과영상학진단,장기분위골미전이조화골전이조량조.병정집아원건강체검인군41례작위건강대조조,분별정량측정혈청ICTP、OC화감성린산매(ALP)농도.결과 혈청ICTP재폐암화유선암골전이조[(27.80±11.14)μg/L화(122.33±34.92)μg/L]균현저고우골미전이조[(8.95±3.81)μg/L화(8.40±4.59)μg/L],차이유통계학의의(P<0 01),골미전이조교건강대조조[(5.16±1.76)μg/L]역유겁현저성차이(P<0.01),혈청OC치재유선암골전이조[(69.31±36.17)ng/mL]역현저고우골미전이조[(15.54±6.09)ng/mL],차이유통계학의의(P<0.01),이폐암골미전이조혈청OC치교건강대조조이급폐암골전이조교폐암골미전이조차이균무통계학의의(P>0.05).혈청ICTP재진단폐암화유선암골전이중시특이성고、민감도교호적지표,혈청OC재진단폐암골전이중단독사용민감도불구,의의불대,단재진단유선암골전이시특이도화민감도균교호.량자연합진단유선암골전이적민감도위96.3%,특이도위96.7%,연합진단폐암골전이적민감도위80.3%,특이도위84.2%.결론 가근거수요단독혹연합응용혈청ICTP화OC,작위제영상학외진단종류골전이유용적실험실진단지표.
Objective To investigate the clinical application of serum marker of bone resorption pyridinoline cross-linked carboxy-terminal telopeptide of type Ⅰ collagen (ICTP) and bone formation marker osteocalcin (OC) in osseous metastasis in tumor patients.Methods Based on pathological and radiological findings, all patients were divided into 3 groups: osseous metastasis group, including 9 lung cancer and 6 breast cancer patients with osseous metastasis;non-osseous metastasis group, including 56 lung cancer and 30 breast cancer patients without osseous metastasis;and control group, including 41 normal individuals. Serum levels of ICTP, OC and alkaline phosphatase (ALP) were quantitatively determined.Results Serum ICTP level was significantly higher in osseous metastasis group than that of non-osseous metastasis group [lung cancer patients: (27.80±11.14) vs (8.95±3.81)μg/L;breast cancer patients: (122.33±34.92) vs (8.40±4.59)μg/L] (P<0.01).There was significant difference between non-osseous metastasis group and control group in serum ICTP level (P<0 01). Serum OC level was also significantly higher in breast cancer with osseous metastasis group than that of breast cancer non-osseous metastasis group [(69.31±36.17) vs (15.54±6.09) ng/mL] (P<0.01),and while there wasn′t statistical difference in serum OC level among lung cancer with osseous metastasis group,non-osseous metastasis group and control group (P>0.05).Serum ICTP was specifici and sensitive in the diagnosis of osseous metastasis in patients with lung cancer or breast cancer.The sensitivity of serum OC was poor in diagnosis of lung cancer with osseous metastasis, but its sensitivity and specificity were both ideal in diagnosis of breast cancer with osseous metastasis.The sensitivity and specificity of combined detection of ICTP and OC was 96.3% and 96.7% for breast cancer with osseous metastasis,80.3% and 84.2% for lung cancer with osseous metastasis,respectively.Conclusion Taken singly or jointly, serum ICTP and OC may be employed as useful laboratory diadynamic criteria in diagnosis of osseous metastasis in tumor patients besides radiological findings.
