CAJ | 학술논문

目的检测2008年度临床分离的淋球菌对青霉素、四环素、大观霉素、头孢曲松和环丙沙星的敏感性,分析耐药菌株的流行特点.方法采用琼脂稀释法测定菌株对5种抗生素的最小抑菌浓度(MIC),判断其敏感性并按WHO西太平洋地区淋球菌耐药性监测统一标准.用纸片酸度法检测产β-内酰胺酶淋球菌菌株.结果 107株淋球菌中,检出94株对青霉素耐药(87.9%),产β-内酰胺酶淋球菌43株(40.2%);四环素耐药率为88.8%,其中质粒介导高度耐四环素淋球菌(TRNG)63株(58.9%);环丙沙星耐药率81.3%;未发现对大观霉素和头孢曲松耐药菌株.青霉索、四环素和环丙沙星的MIC50及MIC90均已超过耐药标准,尤以青霉素为甚,其MIC50及MIC90均超过耐药标准1、32倍.结论淋球菌对大观霉素和头孢曲松的敏感性较高,可作为治疗的首选药物;对青霉素、四环素和环丙沙星耐药率较高,提示对淋病的治疗作用差.
목적 검측2008년도림상분리적림구균대청매소、사배소、대관매소、두포곡송화배병사성적민감성,분석내약균주적류행특점.방법 채용경지희석법측정균주대5충항생소적최소억균농도(MIC),판단기민감성병안WHO서태평양지구림구균내약성감측통일표준.용지편산도법검측산β-내선알매림구균균주.결과 107주림구균중,검출94주대청매소내약(87.9%),산β-내선알매림구균43주(40.2%);사배소내약솔위88.8%,기중질립개도고도내사배소림구균(TRNG)63주(58.9%);배병사성내약솔81.3%;미발현대대관매소화두포곡송내약균주.청매색、사배소화배병사성적MIC50급MIC90균이초과내약표준,우이청매소위심,기MIC50급MIC90균초과내약표준1、32배.결론 림구균대대관매소화두포곡송적민감성교고,가작위치료적수선약물;대청매소、사배소화배병사성내약솔교고,제시대임병적치료작용차.
Objective To investigate the antimicrobial susceptibility and the resistant trend of Neisseria gonorrhoeae strains isolated in Panyu in 2008 to penicillin,tetracycline,spectinomycin,ceftriaxone and eiprofloxacin.Methods The agar dilution method was used to determine the minimum inhibitory concentrations(MIC)to the above five antibiotics.The sensitivities of all strains to the five antibiotics were judged according to criteria used in the project of surveillance of gonococcal antibiotic susceptibility in the WHO Western Pacific Region.Penicillinase-producing Neisseria gonorrhoeae(PPNG)was detected by the paper acidometric method.Results In 107 isolates of Neisseria gonor rhoeae,94 cases(94/107,87.9%)were penicillin-resistant bacteria,and 43 cases(43/107,40.2%)were PPNG ones.The resistance rate of Neisseria gonorrhoeae isolates was 88.8% to tetracycline;63 strains(58.9%)were plasmid-mediated high level tetracycline-resistant(TRNG);the ciprofloxacin resistance rate was 81.3%.Neither spectinomycin nor eeftriaxone-resistant strains were detected.MIC50 and MIC90 of penicillin,tetracycline and ciprofloxacin significantly exceeded the resistance standards,especially 1 and over 32 times higher for penicillin.Conclusion Neisseria gonorrhoeae is sensitive to spectinomycin and ceftriaxone,and the two antibiotics may be used as the first choice to treat Neisseria gonorrhoeae infection.The resistance rates of Neisseria gonorrhoeae to penicillin,tetracycline and eiprofloxacin are relatively high,indicating the three antibiotics are insensitive to gonorrhea.