CAJ | 학술논문

目的:研究肿瘤转移相关基因Ezrin在鼻咽癌组织中的表达并探讨其临床意义.方法:取38例鼻咽癌患者癌组织及20例鼻咽黏膜慢性炎症患者的鼻咽组织行免疫组织化学二步法检测Ezrin蛋白的表达,比较它们的表达结果;并分析鼻咽癌组织Ezrin的表达与患者的临床资料,如性别、年龄、分期、复发、淋巴结转移等的关系.结果:鼻咽癌组织和癌旁黏膜的Ezrin蛋白表达与鼻咽黏膜慢性炎组织相比差异有统计学意义(P＜0.05或P＜0.01),但鼻咽癌组织和其癌旁黏膜Ezrin表达差异无统计学意义(P＞0.05);speanTIan等级相关分析显示,癌组织中Ezrin蛋白表达率随着患者年龄增大而增加(P＜0.05),而与患者性别、临床分期、复发、淋巴结转移无显著相关(均P＞0.05);线性回归分析显示,Ezrin对患者的生存时间有显著影响(P＝0.01).结论:Ezrin对鼻咽癌患者的预后有判断价值.
목적:연구종류전이상관기인Ezrin재비인암조직중적표체병탐토기림상의의.방법:취38례비인암환자암조직급20례비인점막만성염증환자적비인조직행면역조직화학이보법검측Ezrin단백적표체,비교타문적표체결과;병분석비인암조직Ezrin적표체여환자적림상자료,여성별、년령、분기、복발、림파결전이등적관계.결과:비인암조직화암방점막적Ezrin단백표체여비인점막만성염조직상비차이유통계학의의(P＜0.05혹P＜0.01),단비인암조직화기암방점막Ezrin표체차이무통계학의의(P＞0.05);speanTIan등급상관분석현시,암조직중Ezrin단백표체솔수착환자년령증대이증가(P＜0.05),이여환자성별、림상분기、복발、림파결전이무현저상관(균P＞0.05);선성회귀분석현시,Ezrin대환자적생존시간유현저영향(P＝0.01).결론:Ezrin대비인암환자적예후유판단개치.
Objective: To investigate the expression and clinical significance of Ezrin, a tumor metastasis related gene, in tissues of nasopharyngeal carcinoma (NPC). Methods: The expression of Ezrin was detected with two-step immunohistochemistry technique in tissues of 38 NPC patients and 20 nasopharyngitis patients. All of the Ezrin expression and clinical data (gender, age, clinical stage, recurrence, and ]ymphonode metastasis) were compared and analyzed between two groups. Resuits: The Ezrin expressions were significantly different between NPC tissue (and peri-NPC tissue) and naeopharyngitis tissue (P＜0.05). No significant difference was found in the Ezrin expressions between the NPC tissue and the peri-NPC tissue (P＞0.05). It was found by Spearman analysis method that the Ezrin expression increased with patients' age (P＜0.05), but no significam relationship with gender, clinical stage, recurrence, and lymphonode metastasis (P＞0.05). The Ezrin expression influenced the survival time of NPC patients significantly (P＜0.01). Conclusion: The Ezrin expression can be an useful prognostic factor for NPC patients.