CAJ | 학술논문

目的:探讨高压氧(HB0_2)对人牙周炎牙周袋底专性、兼性厌氧菌及产黑色素菌群(BPB)的作用.方法: 将60例牙周炎患者随机分为HB0_2组和对照组,HB0_2组初诊时作龈上洁治术,每日给予0.25 MPa HB0_2治疗80 min,中间吸空气10 min,对照组只作龈上洁治.对2 组患者治疗前后牙周袋底专性和兼性厌氧菌分离培养计数,比较2 组间厌氧菌和BPB差异.结果: 治疗后HB0_2组GI、PD、AL与对照组相比差异有显著性(P<0.01),PLI和松动度(TM)明显降低(P<0.05).治疗后HB0_2组与对照组牙周袋底的厌氧菌数差异有显著性(P<0.01),HB0_2组专性厌氧菌种类较治疗前明显降低(P<0.01),兼性厌氧菌种类明显降低(P<0.05),HB0_2组BPB阳性率(33.3%)与对照组(90%)比差异有显著性;对照组治疗前后厌氧菌数差异无显著性.结论: HB0_2对人侵袭性和慢性牙周炎均有治疗作用,其作用机制为HB0_2对牙周袋底专性厌氧菌、兼性厌氧菌和BPB有明显的抑制作用,对专性厌氧菌作用强于兼性厌氧菌.
목적:탐토고압양(HB0_2)대인아주염아주대저전성、겸성염양균급산흑색소균군(BPB)적작용.방법: 장60례아주염환자수궤분위HB0_2조화대조조,HB0_2조초진시작간상길치술,매일급여0.25 MPa HB0_2치료80 min,중간흡공기10 min,대조조지작간상길치.대2 조환자치료전후아주대저전성화겸성염양균분리배양계수,비교2 조간염양균화BPB차이.결과: 치료후HB0_2조GI、PD、AL여대조조상비차이유현저성(P<0.01),PLI화송동도(TM)명현강저(P<0.05).치료후HB0_2조여대조조아주대저적염양균수차이유현저성(P<0.01),HB0_2조전성염양균충류교치료전명현강저(P<0.01),겸성염양균충류명현강저(P<0.05),HB0_2조BPB양성솔(33.3%)여대조조(90%)비차이유현저성;대조조치료전후염양균수차이무현저성.결론: HB0_2대인침습성화만성아주염균유치료작용,기작용궤제위HB0_2대아주대저전성염양균、겸성염양균화BPB유명현적억제작용,대전성염양균작용강우겸성염양균.
Objective: To investigate the effects of hyperbaric oxygen(HB0_2) on black pigmented bacteroides groups(BPB), obligately and facultatively anaerobes of periodontitis. Methods: 60 periodontitis cases were divided into 2 groups. The HB0_2 group(gingival scaling was done at the first visit)was exposed in 0.25 MPa pure oxygen 90 minutes each day, and treated 10 days continuously. The control group received gingival scaling at the first visit. The clinical indices of each group were measured. The microorganisms in periodontal pocket were incubated and analyzed. The number of subgingival anaerobes as well as the number of BPB,obligately and facultatively anaerobes were measured and counted by routine anaerobic culture. Results: Highly significant differences in Gingival Indices (GI), Probing Depth (PD), Attachment Loss (AL), and also significant differences in Plaque Index (PLI),and teeth mobility were seen between the HB0_2 group and the control group. There were significant difference of PLI, GI,PD,AL, teeth mobility in HB0_2 group pre-therapy and post-therapy. There were significant difference of subgingival anaerobes amounts, obligately and facultatively anaerobes sorts between pre-therapy and post-therapy. The positive rate of BPB of group HB0_2 post-therapy were reduced more than that of pre-therapy(P<0.01). Conclusion: HB0_2 has beneficial therapeutic effects on chronic and aggressive periodontitis. The mechanism of the HB0_2 therapy might inhibit the growth of subgingival obligately and facultatively anaerobes and BPB of human periodontitis, especially the obligately anaerobes and BPB in periodontal pockets.